Training Grant in Dynamic Aspects of Chemical Biology

描述（由申请人提供）：本申请要求继续支持堪萨斯大学化学系、药物化学系、分子生物科学系和药物化学系化学生物学动态方面的博士培训项目。本专业旨在培养具有生物信息工作水平和技能的化学类博士研究生和具有化学信息工作水平和技能的生物类博士研究生。堪萨斯大学的这个项目利用了当地50多年来科学家在化学、生物学和制药科学领域密切有效合作的传统。导师将从参与项目的院系中抽取：化学系17人，分子生物科学系12人，药物化学系8人，药物化学系6人。要求支助8名受训人员，比上次提出的申请增加两名。学员完成一个项目，其特点是在一个既定的实力领域集中博士教育和研究；将受训者的知识和技能扩展到超出部门界限的领域的一系列课程；研究轮转，让学员在项目的各个领域获得个人研究经验；参加特别研讨会和年度专题讨论会的组织和发言。学员的博士研究项目都围绕着在化学层面探索生物系统的共同主题：(1)生物探针的合成；(2)跨生物膜递送探针；(3)生物大分子的结构与功能；(4)生物系统中探针的检测与定量；(5)功能基因组学和生物信息学。培训资助课程从生物信息学和/或分子建模、有机反应原理和科学完整性等核心课程开始。然后，每个化学实习生都需要参加分子生物科学和药物化学的课程。分子生物科学专业的学生需要学习化学和药物化学课程。最后，医学/药物化学专业的学生需要至少选修一门分子生物科学和化学的课程。此外，学员满足其所在部门的所有博士要求。学员管理和参与年度培训补助金研讨会，并邀请演讲者参加化学生物学研讨会。相关性：本提案的核心是建立化学生物学动态方面的综合培训计划。促进跨学科合作的综合方法对于在化学生物学界面获得更广泛的理解并最终实现改善人类健康的目标至关重要。

DESCRIPTION (provided by applicant): This application requests continued support for the doctoral training program in Dynamic Aspects of Chemical Biology in the Departments of Chemistry, Medicinal Chemistry, Molecular Biosciences, and Pharmaceutical Chemistry at the University of Kansas. This training program aims to educate doctoral graduates in the chemical sciences who will have a working level of biological information and skills, and doctoral graduates in the biological sciences who will have a command of chemical information and skills. The program at the University of Kansas takes advantage of a local tradition of over 50 years of close and effective collaboration among scientists at the interface of chemistry, biology, and the pharmaceutical sciences. Mentors will be drawn from the participating departments: 17 faculty from Chemistry, 12 from Molecular Biosciences, 8 from Medicinal Chemistry, and 6 from Pharmaceutical Chemistry. Support is requested for eight trainees, an increase of two from the previous submission. Trainees complete a program that features focused doctoral education and research in an area of established strength; a curriculum of courses that broadens the information and skills of trainees into areas beyond departmental boundaries; research rotations that giye trainees personal research experience in all areas of the program; and participation in both organization of and presentation at special seminars and an annual symposium. The doctoral research projects of trainees fall into a common theme of probing biological systems at the chemical level: (1) synthesis of biological probes; (2) delivery of probes across biological membranes; (3) structure and function of biological macromolecules; (4) detection and quantitation of probes in biological systems; and (5) functional genomics and bioinformatics. The training grant curriculum begins with core courses in bioinformatics and/or molecular modeling, principles of organic reactions and scientific integrity. Then each chemistry trainee is required to take a course in molecular biosciences and medicinal/pharmaceutical chemistry. A molecular biosciences student is required to take a course in chemistry and medicinal/pharmaceutical chemistry. Finally a student in medicinal/pharmaceutical chemistry student is required to take at least one elective course in molecular biosciences and chemistry. In addition, trainees meet all doctoral requirements of their home departments. Trainees manage and participate in the Annual Training Grant Symposium as well as in inviting speakers for a Chemical Biology seminar. RELEVANCE: At the heart of this proposal is the establishment of an integrated training program in the dynamic aspects of chemical biology. Integrated approaches that foster collaboration across scientific disciplines are paramount to gaining a broader understanding at the chemical biology interface with the ultimate goal of improving human health.