Cardiac MR and CT Research

描述(由申请者提供)：我们为我们的心脏成像研究培训计划寻求NIH的持续支持。请拨资金以支持每年8名研究员。我们的计划强调对基础(PHD)和临床(MD)科学家进行现代心脏磁共振(MR)、正电子发射断层扫描(PET)和计算机断层扫描(CT)成像科学的教育。我们的目标是培养未来心脏成像的领导者，强调新的发展和翻译研究。该培训计划以MGH心脏MR-PET-CT计划为基础，是心脏病学和放射学的联合计划，这种模式极大地增强了合作机会。课程包括授课讲座，包括哈佛公共卫生学院的临床有效性课程、实验室练习和个人研究项目。该项目的一个主要优势是我们优秀的教职员工，他们每个人都在从事心脏成像科学前沿的研究。该学院由21名医学和/或博士科学家组成，他们在心脏病学、放射学、物理学、计算机科学和成果研究方面具有专业知识。他们总共有50多项积极的校外资助，并在基础和临床心脏成像研究的各个方面指导了250多名博士后研究员。麻省理工学院、哈佛医学院和麻省理工学院的教职员工、实习生和有成就的研究人员之间的广泛合作，进一步增加了该计划的科学影响力。广泛接触积极进取的科学家和忠诚的导师，强调个人在科学上的卓越表现，为成功培训领导者在心脏病学中使用这些重要技术提供了条件。在NIH支持的最初四年中，NIH的所有实习生职位都得到了填补，实习生撰写或共同撰写了50多本同行评议的出版物。所有完成培训的学员都获得了学术医学中心的工作人员职位或继续参加学术培训计划。为了加强该计划，我们增加了技术人员和新设备，为受训人员提供了心脏成像科学不断发展的领域的更多研究机会，包括斑块活动的FDG PET成像，使用光学和MR探针的分子成像，动物模型的9.4T成像，新的心脏图像重建方法，以及使用双源心脏CT同时成像化学应激期间的狭窄和功能。

DESCRIPTION (provided by applicant): We seek continued NIH support for our Training Program in cardiac imaging research. Funds are requested to support 8 fellows annually. Our program emphasizes the education of basic (PhD) and clinical (MD) scientists in modern cardiac magnetic resonance (MR), positron emission tomography (PET) and computed tomography (CT) imaging science. Our goal is to develop future leaders of cardiac imaging, emphasizing novel developmental and translational research. The training program, based in the MGH Cardiac MR-PET-CT Program, is a joint cardiology and radiology program, a model which greatly enhances opportunities for collaboration. The curriculum consists of didactic lectures including the clinical effectiveness course at the Harvard School of Public Health, laboratory exercises and individual research projects. A major strength of the Program is our outstanding faculty, each of whom are pursuing research at the cutting-edge of cardiac imaging science. The faculty consists of 21 MD and/or PhD scientists with expertise in cardiology, radiology, physics, computer science and outcomes research. Collectively they have over 50 active extramural grants and have supervised over 250 pre/post doctoral fellows in various aspects of basic and clinical cardiac imaging research. Extensive collaboration among the faculty, trainees, and accomplished investigators throughout the MGH, Harvard Medical School and MIT communities, further increase the Program's scientific impact. Broad exposure to highly motivated scientists and committed mentors, with an emphasis on individual scientific excellence, provide the conditions for the successful training of leaders in the use of these important technologies in cardiology. During the initial four years of NIH support, all NIH trainee positions were filled, and trainees authored or coauthored over 50 peer-reviewed publications. All finished trainees obtained staff positions in academic medical centers or continued in academic training programs. To enhance the program we have added technical faculty and novel equipment offering additional research opportunities for trainees in evolving areas of cardiac imaging science including FDG PET imaging of plaque activity, molecular imaging using optical and MR probes, 9.4T imaging of animal models, novel cardiac image reconstruction approaches and simultaneous imaging of stenosis and function during chemical stress using a dual source cardiac CT.