Molecular Mechanisms and Genetics of Autoimmunity

描述（由申请人提供）：俄克拉何马州医学研究基金会（OMRF）的“自身免疫分子机制和遗传学”COBRE项目资助了14项研究，产生了240亿基因型，发表了130篇重要手稿，获得了多项NIH拨款的资助，并招募了8名新教员(Susan Kovats博士，Amr Sawaiha医学博士，Mary Beth Humphrey医学博士，Kathy Moser博士，Pat Gaffney医学博士，Jonathan Wren博士，Courtney Gray-McGuire博士，和Marta Alarcon-Riquelme，医学博士)。总之，我们达到了成功的标准。我们的口头禅是通过指导和建立相关基础设施来实现专业成长。我们有几个年轻的科学家做得很好。例如，Swapan K. Nath博士发现ITGAM（又名CD11b， MAC-1, CR3）是系统性红斑狼疮的一个基因，R77H是其可能的致病多态性。他的重要发现已经在其他多项研究中得到证实。Swapan Nath、Mary Beth Humphrey医学博士、Amr Sawaiha医学博士、Susan Kovats博士和Ken Kaufman博士分别获得了R01、R01、R03、R21和VA优异奖的资助。COBRE项目强调指导，改变了我们的科学文化，使之朝着开放、相互鼓励的方向发展，无论教师是高年级还是低年级。这也有助于发展科学事业并产生杰出的科学成果。在接下来的五年里，我们提出了4个研究项目，一个招募研究和一个试点研究。每个COBRE资助的科学家都有独立职业生涯的潜在希望，产生重要的见解和实验。在科学上，它们将由行政核心下具有指导和其他功能的核酸和数据分析核心提供支持。此外，征聘工作的成功将通过一个征聘核心继续下去，该核心旨在为正在进行的OMRF的扩大提供辅助支助。随着竞争的更新，我们的计划是建立尽可能多的富有成效的科学事业，为我们的机构提供尽可能多的优秀教职员工，提高我们在自身免疫方面的卓越科学成就的国际声誉，并在此过程中产生至关重要的新发现。

DESCRIPTION (provided by applicant): The COBRE Program in the "Molecular Mechanisms and Genetics of Autoimmunity" at the Oklahoma Medical Research Foundation (OMRF) has sponsored 14 studies, generated >240,000,000 genotypes, published 130 important manuscripts, made possible the funding of multiple NIH grants, and has resulted in recruiting of 8 new faculty members (Susan Kovats, PhD, Amr Sawaiha, MD, Mary Beth Humphrey, MD, PhD, Kathy Moser, PhD, Pat Gaffney, MD, Jonathan Wren, PhD, Courtney Gray-McGuire, PhD, and Marta Alarcon-Riquelme, MD, PhD). All in all, we have met the standard for success. Our mantra is professional growth through mentoring and through building relevant infrastructure. Several of our junior scientists have done well. For example, Swapan K. Nath, PhD, identified ITGAM (aka CD11b, MAC-1, CR3) as a gene for systemic lupus erythematosus and R77H as its probable causative polymorphism. His essential findings have been confirmed in multiple other studies. Swapan Nath, Mary Beth Humphrey, MD, PhD, Amr Sawaiha, MD, Susan Kovats, PhD, and Ken Kaufman, PhD have been funded respectively, by an R01, another R01 an R03, an R21, and a VA Merit Award. With its emphasis on mentoring our COBRE Program has changed our scientific culture toward open, mutual encouragement of faculty, whether senior or junior. This has also served to develop careers in science and to produce outstanding scientific results. To begin the coming five years we present 4 research projects, a recruiting study and one pilot study. Each COBRE scientist funded holds the potential promise for an independent career, producing critical insights and experiments. Scientifically, they will be supported by Nucleic Acid and Data Analysis Cores with mentoring and other functions under an Administrative Core. In addition, the recruiting successes will be continued with a Recruiting Core designed to provide adjunct support to the expansion underway at the OMRF. With the competitive renewal, our plan is to build as many productive scientific careers as possible, to populate our institutions with as many exceptional faculty members as possible, to enhance our international reputation for scientific excellence in autoimmunity, and to produce critically important new discoveries in the process. PUBLIC HEALTH RELEVANCE (provided by applicant): Autoimmune diseases are estimated to afflict as many as 50,000,000 of our fellow citizens. This COBRE Program will study process, identify genes, and develop knowledge basic to understanding these disorders, concentrating on systemic lupus erythematosus, a potentially deadly autoimmune disease, found mainly in young women, so that the new knowledge will lead to new diagnostics, prognostics and therapeutics.