Emory Parkinson's Disease Collaborative Environmental Research Center

Emory Parkinson's Disease Collaborative Environmental Research Center（PD-CERC） 埃默里大学合作中心帕金森氏病研究过去的成功的基础上，我们提出了一个综合和协作中心，旨在了解如何环境毒物，如农药，有助于帕金森氏病的发病机制。在过去的几年里，我们的研究小组已经确定了似乎参与PD发病和进展的关键机制，特别是那些由环境因素引发的机制。我们中心的目标是更好地了解环境毒物如何破坏多巴胺稳态，线粒体功能和黑质氧化还原平衡，以及受影响的神经元如何对这些损伤作出反应。由于许多这些扰动并不局限于黑质纹状体多巴胺系统，甚至大脑，有一个令人兴奋的机会，以确定外周生物标志物的这些过程中的oatients血清中使用新的代谢组学方法。该中心的总体主题是，环境毒物，如杀虫剂，通过特定的分子靶点破坏氧化还原状态;神经元防御这些变化的固有能力决定了帕金森病中受影响的神经元是存活还是死亡。PD-CERC有五个主要目标：1。到 确定多巴胺储存的环境和遗传破坏如何导致氧化 伤害，2.确定多巴胺神经元响应线粒体功能障碍和氧化应激的新机制，3.以确定环境毒物如何破坏细胞和外周室中的氧化还原平衡，4.鉴定环境毒物和特发性PD的新型代谢组学生物标志物，5.通过招募研究人员，激发新的想法，促进新的项目，并为年轻的研究人员提供职业发展，充实中心。整合有关线粒体功能障碍、多巴胺代谢和氧化应激的信息，以指导未来PD的预防、诊断和治疗策略。这些目标的完成将提高我们对环境毒物如何增加PD风险的理解，并为制定旨在减轻PD环境暴露不良影响的治疗干预措施奠定基础。

Emory Parkinson's Disease Collaborative Environmental Research Center (PD-CERC). Building upon the past successes of the Emory University Collaborative Center for Parkinson's Disease Research, we propose an integrated and collaborative center that is aimed at understanding how environmental toxicants, such as pesticides, contribute to the pathogenesis of arkinson's disease. Over the past several years our research groups have identified key mechanisms that appear to be involved in the onset and progression of PD, especially those triggered by environmental factors. The goal of our center is to better understand how environmental toxicants disrupt dopamine homeostasis, mitochondrial function, and redox balance n the substantia nigra, and how the affected neurons respond to these insults. Since many of these perturbations are not restricted to the nigrostriatal dopamine system or even the brain, there is an exciting opportunity to identify peripheral biomarkers of these processes in the serum of oatients using novel metabolomic methods. The overall theme of the center is that environmental toxicants, such as pesticides, act through specific molecular targets to disrupt redox state; and it is the inherent ability of the neurons to defend against these changes that dictate whether the neurons affected in Parkinson's disease survive or die. The PD-CERC has five major objectives: 1. to determine how environmental and genetic disruption of dopamine storage leads to oxidative damage, 2. to identify novel mechanisms by which the dopamine neurons respond to mitochondrial dysfunction and oxidative stress, 3. to determine how environmental toxicants disrupt redox balance in cellular and peripheral compartments, 4. to identify novel metabolomic biomarkers of environmental toxicants and idiopathic PD, 5. to enrich the center through recruitment of investigators, stimulation of new ideas, fostering of new projects, and by providing career development to young investigators and 6. To integrate information on mitochondrial dysfunction, dopamine metabolism, and oxidative stress to guide future strategies for the prevention, diagnosis, and treatment of PD. Completion of these objectives will improve our understanding of how environmental toxicants increase the risk of PD and it will lay the foundation for tailoring therapeutic interventions aimed at mitigating the adverse effects of environmental exposures in PD.