Life Course Socioeconomics, Acculturation, & Type-2 Diabetes Risk Among Latinos

描述(由申请者提供)：在美国的拉美裔人患有不成比例的2型糖尿病。研究表明，生命周期的社会经济地位是慢性疾病发展的一个主要因素，例如2型糖尿病；然而，大多数证据仅限于非西班牙裔白人人口。我们假设，拉美裔人中2型糖尿病的巨大差异反映了社会经济因素、文化特征、行为、生物学和其他风险因素在过去几年积累的代际传递的共同影响。 生命历程。拉美裔在美国的经历代表了一个特别富有成效的背景 目的探讨生命周期、社会经济和文化资源对2型糖尿病的影响。除了是肥胖率和2型糖尿病发病率最高的增长最快的少数族裔人口外，拉美裔美国人的经历还包括教育和工作技能有限的第一代移民，以及在美国出生和长大并表现出不同程度的文化适应和同化、行为变化和社会经济进步的后代。考虑到这些独特的考虑，本研究试图：(1)考察生命过程社会经济地位对拉丁裔2型糖尿病的影响；(2)评估文化适应是否改变生命过程社会经济地位对拉丁裔2型糖尿病的影响；以及3)检验与行为、生理和心理社会危险因素相关的代谢和炎症标记物是否在拉丁裔生命过程社会经济地位、文化适应和2型糖尿病之间的关系中起中介作用。拟议的研究活动将是第一次系统地尝试评估拉丁美洲人的生命过程、社会经济地位和文化适应对2型糖尿病的独特和协同作用。通过评估居住在美国的两代拉美裔美国人的生活过程，该项目提供了一个前所未有的机会，以确定早期干预的目标，以减轻拉美裔人中沉重的2型糖尿病负担。更广泛地说，拟议的研究可能揭示生命过程中关键的风险因素或促进健康的特征的社会经济和文化模式，这些特征也可能使生活在贫困中并患有2型糖尿病的其他种族/少数民族不成比例地受益。

DESCRIPTION (provided by applicant): Latinos in the US carry a disproportionate burden of type-2 diabetes. Research has implicated life course socioeconomic position as a major factor in the development of chronic diseases, such as type-2 diabetes; yet most evidence is limited to non-Hispanic White populations. We hypothesize that the large disparities in type-2 diabetes among Latinos reflects the joint effect of intergenerational transmission of socioeconomic factors, cultural characteristics, behaviors, biology, and other risk factors accumulating over the life course. The experience of Latinos in the US represents an especially fruitful context in which to investigate the influence of life course socioeconomic and cultural resources in relation to type-2 diabetes. In addition to being the fastest growing minority population with high rates of obesity and type-2 diabetes, the experience of Latinos is one that includes first generation immigrants with limited education and job skills, and later generations who are born and raised in the US and show varying levels of acculturation and assimilation, behavioral change, and socioeconomic advancement. With these unique considerations in mind, the present study seeks to: (1) examine the impact of life course socioeconomic position on type-2 diabetes among Latinos; (2) assess whether acculturation modifies the impact of life course socioeconomic position on type-2 diabetes among Latinos; and 3) examine whether metabolic and inflammatory markers related to behavioral, physiological, and psychosocial risk factors mediate the relationships between life course socioeconomic position, acculturation, and type-2 diabetes among Latinos. The proposed research activity will constitute the first systematic attempt to assess the unique and synergistic contributions of life course socioeconomic position and acculturation on type 2 diabetes among Latinos. By assessing life course exposures across two generations of Latinos living in the US, this project provides an unprecedented opportunity to identify targets for early intervention for reducing the heavy burden of type-2 diabetes among Latinos. More broadly, the proposed research may uncover crucial life course socioeconomic and cultural patterning of risk factors or health promoting characteristics that may also benefit other race/ethnic minorities disproportionately living in poverty and suffering from type-2 diabetes.