New York State BD-STEPS

该项目的目的是确定怀孕早期可改变的母亲暴露， 可能会增加怀孕受某些重大结构性出生缺陷影响的风险。 受助者将使用现有出生缺陷监测系统的数据， 17种出生缺陷这些病例婴儿的母亲和随机选择的 将联系活产对照婴儿并邀请其参加母亲访谈。 访谈将集中在以下关键领域：（1）糖尿病，肥胖和体力活动;（2）其他 慢性孕产妇疾病;（3）不孕症;（4）药物使用;除其他外， 具有预防潜力的暴露，如泌尿生殖系统感染、发热， 母亲的职业试剂盒将邮寄给参与的家庭，以收集唾液样本， 将为收集残留的新生儿血斑提供经费， 基因-环境相互作用研究的潜力。

The purpose of this project is to identify modifiable maternal exposures in early pregnancy that may increase the risk for having a pregnancy affected by certain major, structural birth defects. Grantees will use data from existing birth defects surveillance systems to identify children with the 17 birth defects categories. Mothers of these case infants and mothers of randomly selected live born control infants will be contacted and invited to participate in a maternal interview. The interview will focus on the key areas of: (1) diabetes, obesity, and physical activity; (2) other chronic maternal medical conditions; (3) infertility; and (4) medication use; in addition to other exposures with promising prevention potential such as genitourinary infections, fever, and maternal occupation. Kits will be mailed to participating families to collect saliva samples and provisions will be made for the collection of residual newborn bloodspots, enhancing the potential for gene-environment interaction studies.