Mentoring Program for Translational and Patient Oriented Research in AKI

描述（由申请人提供）：急性肾损伤（AKI）是住院患者的常见并发症，已知会对短期和长期预后产生不利影响。K24拨款的目的是为Parikh博士的病人导向研究（POR）项目提供支持，并为对这些研究领域感兴趣的学员提供指导活动。Parikh博士目前作为首席研究员，在各种AKI环境中发现和验证生物标志物的研究得到联邦拨款的支持。Parikh博士还创建了研究生物标志物终点的转化研究（TRIBE）联盟，用于发现和验证生物标志物。这些资助的研究，以及通过TRIBE联盟开展的各种其他多中心合作，为Parikh博士的学员提供了培训和独立研究的机会。自2000年以来，Parikh博士已经指导了20多名住院医生或研究人员，并在40多篇同行评审的文章中担任高级作者[他的学员为第一作者]。他之前的三位学员目前是面向患者的研究人员，并在学术机构担任教职。他的学员将获得T32国家肾脏病研究服务奖和其他奖学金资助。作为指导计划的一部分，所有受训者将完成1)教学培训——临床研究方法论课程；2)一个研究项目-一个基于假设的项目由Dr. Parikh和多学科教员监督；3)通过撰写助学金和在会议上演讲来训练书面和口头陈述。所有学员还将被要求参加临床研究伦理学的结构化课程。该K24应用程序还包括使用三个不同的AKI队列和三个互补的蛋白质组学技术发现AKI恢复的生物标志物的新建议。

DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is a common complication in hospitalized patients and is known to adversely impact short-term and long-term outcomes. The aim of the K24 grant is to provide support for Dr. Parikh's patient oriented research (POR) program and his mentoring activities for trainees interested in these research areas. Dr. Parikh is currently supported by federal grants as Principal Investigator for his research on the discovery and the validation of biomarkers in various settings of AKI. Dr. Parikh has also created the Translational Research Investigating Biomarker End-points (TRIBE) consortium for discovery and validation of biomarkers. These funded studies, as well as a wide variety of other multicenter collaborations through the TRIBE consortium, provide opportunities for training and independent research for Dr Parikh's trainees. Since the year 2000, Dr. Parikh has mentored over 20 residents or research fellows, and been senior author on over 40 peer-reviewed articles [with his mentee as the first author]. Three of his previous mentees are currently patient-oriented researchers and hold faculty positions at academic institutions. His mentees would be supported by a T32 National Research Service Award to the Section of Nephrology and other fellowship grants. As a part of the mentoring program, all trainees will complete 1) didactic training - course work in clinical research methodology; 2) a research project - a hypothesis-based project supervised by a Dr. Parikh and a multi-disciplinary faculty member; and 3) training in written and oral presentation by writing grants and presenting in conferences. All mentees will also be required to participate in a structured curriculum of ethics in clinical research. This K24 application also includes a new proposal for the discovery of biomarkers of recovery from AKI, using three different AKI cohorts and three complementary proteomic techniques.