Infectious Disease Genomics and Bioinformatics Training in Brazil

这项提议代表了目前ITGH D43合作培训伙伴关系的延续 佐治亚大学、里约热内卢奥斯瓦尔多·克鲁兹-菲奥克鲁斯研究所的研究人员 米纳斯吉拉斯联邦大学和佩斯基萨雷内·拉丘中心(CPqRR)-Fiocruz in 贝洛奥里藏特，巴西。CPqRR目前拥有14个实验室和5个由NIH资助的研究奖项。这个 这项培训提案的目标是在CPQRR在以下领域建立可持续的核心基础设施 生物信息学、流行病学和分子进化，将补充现有的NIH资助的研究和 促进在其他实验室进行的研究。CPqRR的研究重点是热带寄生虫， 它们的媒介和宿主。这些生物包括：疟原虫、克鲁氏锥虫。弓形虫 刚地虫、曼氏血吸虫。按蚊、白纹伊蚊和人类。 这项提议旨在通过继续一个非常有成效的培训方案来满足CPQRR的需求 这涉及来自CPQRR 14个实验室中许多实验室的博士后和博士后，他们需要额外的 五年了。高级培训将通过研讨会、课程、短期和长期培训进行 在巴西国内和国外。培训将涉及源自以下需求的合作研究项目 CPqRR和关注血吸虫病的几个方面。本次培训的统一项目将是 继续维护和扩展(包括种群多样性和其他“组学”数据) 血吸虫基因组数据库在培训奖的第一阶段创建并保存了CPqRR。 分子进化培训将集中在血吸虫媒介、血吸虫和 流行病学/生物统计数据将从现有的资助项目中得出和分析。这个 从培训和实施工作中获得的技术和知识将直接适用 来研究其他寄生生物。我们将积极物色合格的人才进行培训。 他们强烈希望回国，并为继续开展一项 新成立的生物信息学中心。 相关性(请参阅说明)： 针对寄生虫病的新药和疫苗靶标的需求是巨大的。技术的进步 为我们提供了新的数据，涵盖了寄生虫生物学的许多方面。但是，新的数据 是复杂的，需要复杂的计算分析和数据库。这项提议旨在 培训流行地区的新一代研究人员使用这些新数据来帮助治愈疾病。

This proposal represents a renewal of a current ITGH D43 collaborative training partnership between researchers at the University of Georgia, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro, the Universidade Federal de Minas Gerais and the Centro de Pesquisas Rene Rachou (CPqRR) - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 14 laboratories and 5 funded NIH research awards. The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH-funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR Is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans. This proposal is designed to meet the needs ofthe CPqRR by continuing a very productive training program that involves pre-and post-doctoral students from many of the 14 laboratories at the CPqRR for an additional 5 years. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the continued maintenance and extension (to include population diversity and other "omics" data) of a Schistosoma genome database created and housed the CPqRR during the first phase of the training award. Molecular evolution training will focus on the Schistosome vector, Blomphalaria and epidemiological/biostatistlcal data will be derived and analyzed from existing funded projects. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a newly founded Center of Bioinformatics. RELEVANCE (See instructions): The need for new drug and vaccine targets for parasitic diseases is tremendous. Advances in technology have provided us with new data that cover many aspects of the biology of the parasites. But, the new data are complex and require sophisticated computational analyses and databases. This proposal is designed to train a new generation of researchers in endemic areas to use this new data to help cure disease.