FASEB SRC on The Biology of Calpains in Health and Disease

描述（由申请人提供）：FASEB夏季会议计划于2013年7月召开，主题为“健康与疾病中的calpain生物学”。这是第六次以加利福尼亚为重点的会议，将在佛蒙特州的萨克斯顿河举行。六个不同的NIH研究所正在申请资金，NINDS作为主要任务，NCI、NHLBI、NIA、NIDDK和NIAMS作为次要任务。从这些研究所获得的资金将为会议提供部分支助。会议将有两个主要重点；1)了解钙蛋白酶的生化特性，2)了解钙蛋白酶在各种疾病过程中的作用。会议计划有8个主题，包括：1)钙蛋白酶底物的生物信息学，2)钙蛋白酶与癌症，3)钙蛋白酶激活的测量，3)钙蛋白酶在细胞死亡途径中的作用，4)钙蛋白酶在糖尿病中的作用，5)钙蛋白酶在神经退行性疾病和脑损伤中的作用，6)钙蛋白酶在心血管疾病中的作用，7)钙蛋白酶抑制剂的治疗作用，8)钙蛋白酶在肌肉中的作用。彼得·戴维斯博士将是主讲人。Davies博士对我们理解钙蛋白酶的结构以及内源性钙蛋白酶抑制剂calpastatin的作用机制做出了开创性的贡献。关于钙痛的生物学会议与NIH高度相关，因为钙痛参与了正常和病理过程。管家蛋白的活动对所有组织中正常的蛋白质周转和细胞骨架蛋白和膜蛋白的加工都很重要。钙蛋白酶或钙蛋白酶底物的突变与疾病和致死率有关。本次会议讨论的疾病将包括衰老、阿尔茨海默病、肌萎缩侧索硬化症、心房颤动、心脏缺血性损伤、脑缺血、心脏肥厚、糖尿病、马查多-约瑟夫病、疟疾、肌肉萎缩症、中风、创伤性脑损伤和血管重塑。自上次calpain会议以来已经过去了三年，在基因组学、结构、激活和疾病中的作用方面取得了实质性进展。拟议的方案将为维持这一领域的势头提供论坛。

DESCRIPTION (provided by applicant): A FASEB summer conference is planned for July 2013 entitled "Biology of Calpains in Health and Disease". This is the sixth such meeting focusing on calpains and it will be held in Saxton Rivers, Vermont. Funds are being requested from six different NIH institutes, with NINDS as the primary and NCI, NHLBI, NIA, NIDDK, and NIAMS as secondary assignments. Funds obtained from these institutes will provide partial support for the meeting. The meeting will have two main emphases; 1) understanding the biochemical properties of calpains and 2) understanding the role of calpains in various disease processes. Eight stimulating sessions are planned for the meeting including 1) Bioinformatics of Calpain Substrates, 2) Calpains and Cancer, 3) Measuring Calpain Activation 3) Calpains in Cell Death Pathways 4) Calpains in Diabetes, 5) Calpains in Neurodegeneration and Brain Injury 6) Calpains in Cardiovascular Disease 7) Calpain inhibitors as therapeutics, and 8) Calpains in Muscle. Dr. Peter Davies will be the keynote speaker. Dr. Davies has made seminal contributions to our understanding of the structure of calpain as well as the mechanism of action of the endogenous calpain inhibitor, calpastatin. A meeting on the biology of the calpains is highly-relevant to the NIH because calpains are involved in both normal and pathological processes. The activities of the house- keeping calpains are important for normal protein turnover and processing of cytoskeletal and membrane proteins in all tissues. Mutations in calpains or in calpain substrates are associated with disease and lethality. Disorders discussed at the this meeting will include aging, Alzheimer's disease, amyotrophic lateral sclerosis, atrial fibrillation, cardiac ischemic injury, cerebral ischemia, cardiac hypertrophy, diabetes, Machado-Joseph disease, malaria, muscular dystrophy, stroke, traumatic brain injury, and vascular remodeling. Three years have passed since the last meeting on calpain and substantial progress on the genomics, structure, activation and roles in disease have been made. The proposed program will provide the forum by which the momentum in this field may be maintained.