Effect of reinforcer type in cognitive behaviors

描述（由申请人提供）：这是一个尖端基础研究奖R21应用程序，旨在了解药物成瘾对认知表现影响的机制。暴露于滥用药物，如阿片类药物，降低了许多基于实验室的工作记忆任务的认知表现，如延迟不匹配样本（DNTMS）程序。我们假设药物诱导的认知任务缺陷可能不一定反映认知能力缺陷，而是可能由药物诱导的非药物刺激与药物刺激在这些程序中强化行为的能力降低所致。目标#1将在非依赖性受试者中评估兴奋剂类型（食物与瑞芬太尼）和剂量对工作记忆表现的影响。目标#2将评估阿片类药物依赖和戒断对食物和瑞芬太尼维持的工作记忆表现的影响。我们的工作假设的证实将挑战目前关于药物成瘾对成瘾相关认知缺陷的影响的想法，涉及成瘾者特异性神经回路在成瘾相关认知缺陷中的作用，并为这些认知缺陷的成瘾者特异性治疗策略的发展提供经验基础。

DESCRIPTION (provided by applicant): This is a Cutting-Edge Basic Research Award R21 application designed to understand the mechanisms underlying the effects of drug addiction on cognitive performance. Exposure to abused drugs, such as opioids, degrades cognitive performance on many laboratory- based working memory tasks, such as the delayed non-match to sample (DNTMS) procedure. We hypothesize that drug-induced deficits in cognitive tasks may not necessarily reflect deficits in cognitive ability, but rather may result from a drug-induce decrease in the ability of non-drug vs. drug stimuli to reinforce behavior in these procedures. Aim #1 will assess the effects of reinforcer type (food vs. Remifentanil) and magnitude on work memory performance in non-dependent subjects. Aim #2 will assess the effects of opioid dependence and withdrawal on working memory performance maintained by food and remifentanil. Confirmation of our working hypothesis would challenge current thinking on the impact of drug addiction on addiction-related cognitive deficits, implicate reinforcer-specific neural circuits in addiction-related cognitive deficits, and provide an empirical foundation for th development of reinforcer-specific treatment strategies of these cognitive deficits.