Midcareer Investigator Award in Patient-Oriented NeuroAIDS Research

描述（由申请人提供）：Scott Letendre，医学博士是UCSD的医学副教授和前K23职业发展奖获得者。在过去的十年中，Letendre博士领导或合作了许多公共和私人资助的转化研究项目。他有影响力的工作集中在美国和国际环境中艾滋病毒相关神经认知障碍（HAND）的风险因素和治疗。在此期间，他还指导了30多名以患者为导向的研究人员，包括研究生和医学生，博士后研究人员和初级教师。在拟议的K24职业中期研究者奖中，Letendre博士将扩大他对初级研究者的指导，并将他的指导和他自己的研究集中在三个主要目标上。神经系统的抗逆转录病毒治疗：Letendre博士将指导学员进行HAND临床试验和CSF药理学项目的设计和执行，特别是专注于测量抗逆转录病毒方案中所有药物的纵向项目，以更好地了解药物相互作用和时间如何影响病毒学和神经认知结果。疾病和治疗的生物标志物相关性：Letendre博士将指导学员测量和分析生物标志物数据，目的是开发一个临床有用的面板，用于HAND的筛查，诊断和预后。这项工作将得到新设备的支持，这些设备是用最近的S10共享仪器赠款购买的。艾滋病毒感染者的合并感染：Letendre博士将与学员一起开展项目，评估潜伏性或轻微症状的病原体感染对神经系统的影响，如疟原虫，巨细胞病毒，弓形虫和丙型肝炎病毒。这项工作将特别侧重于Letendre博士在国际环境中的现有工作。Letendre将使用多学科方法指导学员，包括定期直接参与，参与UCSD的R25，T32和K30计划，积极参与现有的研究项目，支持新的研究项目，并与其他研究人员建立联系。Letendre博士还将获得指导和纵向数据分析方面的培训。总之，这个K24奖将确保Letendre博士有受保护的时间指导神经艾滋病方法的学员，包括负责任地进行以患者为导向的研究。Letendre博士将与其他UCSD资源协调他的努力，包括R25资助的“神经艾滋病国际研究奖学金”，T32资助的“跨学科神经艾滋病成瘾研究培训”，以及CTSA资助的“临床和转化研究所”。

DESCRIPTION (provided by applicant): Scott Letendre, M.D. is an Associate Professor of Medicine at UCSD and former K23 Career Development Award recipient. In the past decade, Dr. Letendre has led or collaborated on many publicly and privately funded translational research projects. His influential work has focused on the risk factors and treatment of HIV-associated neurocognitive disorder (HAND) in the US and international settings. During this period, he has also mentored more than 30 trainees in patient-oriented research, including graduate and medical students, post-doctoral researchers, and junior faculty. In the proposed K24 mid-career investigator award, Dr. Letendre will expand his mentoring of junior investigators and will focus his mentoring and his own research on three main objectives. Antiretroviral treatment of the nervous system: Dr. Letendre will mentor trainees on design and performance of HAND clinical trials and CSF pharmacology projects, particularly focusing on longitudinal projects that measure all drugs in an antiretroviral regimen to better understand how drug interactions and time influence virologic and neurocognitive outcomes. Biomarker correlates of disease and treatment: Dr. Letendre will mentor trainees on measurement and analysis of biomarker data with the goal of developing a clinically useful panel for screening, diagnosis, and prognosis of HAND. This work will be supported by new equipment purchased with funds from a recent S10 Shared Instrument Grant. Coinfections in HIV-infected individuals: Dr. Letendre will work with trainees on projects that evaluate the impact on the nervous system of latent or minimally symptomatic infections with pathogens such as Plasmodium, Cytomegalovirus, Toxoplasma, and hepatitis C virus. This work will particularly focus on Dr. Letendre's existing work in international settings. Dr. Letendre will mentor trainees using a multidisciplinary approach that includes regular direct engagement, participation in R25, T32, and K30 programs at UCSD, active participation in existing research projects, support for new research projects, and networking with other investigators. Dr. Letendre will also obtain training in mentoring and analysis of longitudinal data. In summary, this K24 award will secure protected time for Dr. Letendre to mentor trainees in neuroAIDS methods, including the responsible conduct of patient- oriented research. Dr. Letendre will coordinate his efforts with other UCSD resources, including the R25- funded "International Research Fellowship in NeuroAIDS", the T32-funded "Training in Research on Addictions in Interdisciplinary NeuroAIDS", and the CTSA-funded "Clinical and Translational Research Institute".