Sleep and Processing Traumatic Memory

描述（由申请人提供）：睡眠似乎在重要方面有助于创伤后应激障碍或PTSD的发展和维持，以及从创伤的不利影响中恢复和恢复。然而，关于睡眠和PTSD之间的关系存在不确定性，因此最近在文献中表达了关于睡眠作为巩固与适应性处理创伤记忆的作用的对立观点。这种探索性/发展性研究应用的目标是建立一个范式，用于测试睡眠参数和处理创伤记忆之间的关系。如果成功，假设得到支持，该程序将被应用于开发药理学和其他干预措施，以增强睡眠的益处，并评估睡眠限制和中断的有害影响的阈值。在开发一种新方法的过程中，我们还将评估晚上和早上的书面叙述披露会议的影响，并干预睡眠（夜间和白天评估一天中的时间影响）或醒来，包括其对睡眠的潜在影响，创伤后应激障碍症状和非特异性痛苦。我们将利用受试者内的交叉设计，以确定是否会话的叙事披露与干预睡眠期将更有效地比会话分开的清醒期在影响习惯和适应性情绪处理的其他指标。我们将确定哪些情绪处理指标对睡眠影响最敏感。我们还将评估干预睡眠的特征的影响，包括快速眼动连续性的措施。

DESCRIPTION (provided by applicant): Sleep appears to contribute in important ways to the development and maintenance of posttraumatic stress disorder or PTSD as well as to recovery from, and resilience to adverse effects of trauma. However, uncertainty regarding relationships between sleep and PTSD exists such that opposing views of sleep's role as consolidating versus adaptively processing trauma memories have both been recently expressed in the literature. The goal for this exploratory/developmental research application is to establish a paradigm for testing relationships between sleep parameters and processing trauma memories. If successful, and hypotheses are supported, the procedures will be applied to developing pharmacological and other interventions to enhance sleep's benefits, and to evaluate thresholds for detrimental effects of sleep restriction and disruption. In developing a novel approach we will also be evaluating the effects of written narrative disclosure sessions in the evening and morning with intervening sleep (overnight and daytime to evaluate for time of day effects) or wake, including its potential impact on sleep, PTSD symptoms, and non-specific distress. We will utilize a within subjects cross-over design to determine whether sessions of narrative disclosure with an intervening sleep period will be more effective than sessions separated by a wake period in effecting habituation and other indices of adaptive emotional processing. We will determine which indices of emotional processing are most sensitive to sleep effects. We will also evaluate the influence of characteristics of intervening sleep including measures of REM continuity.