3D Tracking for OCT Image Fusion in Gynecological Diagnosis

描述（由申请人提供）：SBIR二期项目的目标是继续开发一个基于光学相干层析成像采集与实时三维空间定位集成的令人兴奋的平台。在第一阶段，在妇科诊断成像的背景下，我们展示了用于阴道镜/阴道内成像和子宫颈OCT图像之间原型图像融合的硬件和软件。我们还展示了一种有前景的方法来简化三维OCT数据集的获取，这可能具有广泛的应用。在这个项目中，我们以这些有希望的结果为基础来定义和开发两个新产品。第一个将是临床跟踪和软件系统，它将增强OCT成像系统，提供OCT和阴道镜图像之间的融合，以及分析、审查和报告图像发现的工具。第二个将包括软件和成像/跟踪探头，可以很容易地（由最终用户）耦合到商用OCT系统，安装后，将允许从简单的手动扫描的2D数据重建3D OCT数据集。设备将在幻影和动物模型以及临床中进行验证。在该应用继续集中于妇科诊断的同时，我们也将为该技术未来在其他领域的发展奠定重要的实验基础。

DESCRIPTION (provided by applicant): The goal of this Phase II SBIR project is to continue development of an exciting platform based on integration of optical coherence tomography acquisition with real-time 3D spatial localization. In Phase I, in the context of gynecological diagnostic imaging, we demonstrated hardware and software for prototype image fusion between colposcopic/intravaginal imaging and OCT images of the cervix. We also demonstrated a promising methodology for simplified acquisition of 3D OCT data sets which may have broad application. In this project, we build upon these promising results to define and develop two new products. The first will be a clinical tracking and software system which augments an OCT imaging system to provide fusion between OCT and colposcopic images as well as tools for analyzing, reviewing, and reporting image findings. The second will consist of software and an imaging/tracking probe which can be readily coupled (by an end user) to commercially available OCT systems and which, when installed, will allow reconstruction of 3D OCT datasets from simple manually scanned 2D data. Devices will be validated in phantoms and animal models as well as clinically. While this application continues to be focused on gynecological diagnosis, we will also lay important experimental groundwork for future development of this technology in other fields.