RESEARCH PILOT PROJECTS PROGRAM

脂质组学中的COBRE继续从基础科学研究发展到动物模型，现在又发展到转化研究。这一演变要求基础研究不断取得进展，例如在开发生物标志物的技术和能力方面。它还需要吸引翻译科学家到Lipidomics和/或使Lipidomics研究人员能够通过重组进行翻译研究，合作将他们的研究从实验室转向临床应用。MUSC的脂质组学和病理学中心建立在COBRE前两个阶段的重大成就之上，包括指导19名有针对性的初级教师研究人员，以及约30名MUSC研究人员参与COBRE活动。COBRE在招募少数民族和妇女作为目标教师方面也非常成功。其中许多成功是通过向有前途的调查人员提供试点项目而实现的。因此，该计划的总体目标是继续我们从以前的资助周期中获得的重要动力，为翻译和其他试点研究提供并优先考虑短期资金，以迅速确定新想法或技术是否具有足够的优点和可行性向前推进，并成为竞争性NIH研究项目资助申请的基础。为此，我们将在南卡罗来纳州临床和转化研究所（SCTR）开发和维护的信息学工具和网络资源的基础上进行构建和修改，这些工具和网络资源作为CTSA支持的基础设施，为COBRE试点项目计划的申请和进度报告的电子提交和审查开发一个平台。申请请求（RFA）将每年公布。试点项目调查员可申请每年最多50，000美元（直接费用总额最多为100，000美元），最长为期两年（24个月）。每隔6个月提交一次进度报告，并在指定项目期结束时提交一份最终报告。第二年的支持，如果要求，将取决于生产力。该试点项目计划的目标将通过以下方式成功实现：增加提交给NIH和其他生物医学研究赞助商的脂质组学和病理学领域的学术出版物和赠款提案的数量和竞争力;加强MUSC的资源和竞争力，以在脂质组学和病理学领域进行基础，转化和临床研究;巩固我们的中心在脂质组学和病理学的地位，作为一个国家和国际公认的，卓越的基础和转化研究在脂质组学和病理学的独特中心。

The COBRE in Lipidomics continues to evolve from basic science studies to animal models and now to translational research. This evolution requires continued advances in basic research, for example, in technology and ability to develop biomarkers. It also requires attracting translational scientists to Lipidomics and/or enabling Lipidomics investigators to conduct translational research through retooling, collaborating to move their investigations from the bench toward clinical application. The Center in Lipidomics and Pathobiology at MUSC builds on substantial accomplishments during the first two phases of the COBRE, including mentoring of 19 targeted junior faculty investigators and participation by ~30 MUSC research faculty in COBRE activities. The COBRE has also been very successful in recruiting minorities and women as target faculty. Many of these successes were enabled through the granting of Pilot Projects to promising investigators. Therefore, the overall goal of this program is to continue the significant momentum we have gained from the previous funding cycles by providing and prioritizing short-term funding for translational and other pilot studies designed to determine expeditiously whether a novel idea or technology has sufficient merit and feasibility to move forward and become the basis of a competitive NIH research project grant application. To this end, we will build on and modify informatics tools and web resources developed and maintained by the South Carolina Clinical and Translational Institute (SCTR) that serve as CTSA-supported infrastructure to develop a platform for electronic submission and review of applications and progress reports for COBRE Pilot Projects Programs. A request for applications (RFA) will be advertised annually. Pilot project investigators may request up to $50,000/yr (up to a total of $100,000 direct costs) for a maximum of two years (24 months). Progress reports will be required at 6-month Intervals with a final report at the end of the designated project period. Second-year support, if requested, will be contingent on productivity. The goals of this Pilot Projects Program will be successfully met by: Increasing the number and competitiveness of translationally based publications and grant proposals in the field of Lipidomics and Pathobiology submitted to NIH and other biomedical research sponsors; strengthening the resources and competitiveness of MUSC to conduct basic, translational and clinical research in the field of Lipidomics and Pathobiology; and consolidating the stature of our Center in Lipidomics and Pathobiology as a nationally and internationally recognized, unique center of excellence in basic and translational studies In Lipidomics and Pathobiology.