Photograph Reading Center for the Comparison of AMD Treatments Trial

描述(由申请人提供)：AMD治疗比较试验(CATT)是一项多中心随机临床试验，研究Lucentis和阿瓦斯丁治疗新生血管性AMD的情况。此眼底照片阅读中心(FPRC)应用程序中提出的活动的主要目标是为CATT提供支持。这项支持包括A)评估随访眼底照片，以评估两种治疗后脉络膜新生血管的变化和视网膜血管直径的变化；以及B)评估这些发现与CACT OCT阅读中心的结果的相关性。这项延续赠款建议有两个具体目标：目标1，在所有参与者中完成最初的CATT赠款申请的两年后续行动。由于CATT试验的患者登记被推迟，完成两年随访所需的时间必须延长到原始计划中提议的时间段之后。目的2，进行一项观察性研究，再随访3年，以调查研究药物的长期效果。在整个拟议的研究中，FPRC将为CAT提供提交的彩色照片和血管造影图像材料的可靠、及时、可重现和系统的分级。这些活动将类似于CATT研究最初几年提供的活动。研究中心还将继续为读者、摄影师、临床协调员以及眼科医生认证和培训实施研究特定的材料和方法。研究中心的活动还将支持研究目标，将其作为招聘、研究小组会议、演讲和出版物的图像资源。相关性(参见说明)：老年性黄斑变性(AMD)是美国和大多数西方国家的主要致盲原因。这些关于这两种药物相对有效性和安全性的研究将决定未来如何治疗新生血管性(“湿性”)AMD患者。

DESCRIPTION (provided by applicant): The Comparison of AMD Treatments Trial (CATT) is a multi-center, randomized clinical trial investigating the treatment of neovascular AMD with Lucentis and Avastin. The primary objective of the activities proposed in this fundus Photograph Reading Center (FPRC) application is to provide support to the CATT. This support includes A) the evaluation of follow-up visit fundus photographs to assess the changes in the choroidal neovascularization and the changes in retinal vessel diameters following both treatments; and B) assessment of the correlation of these findings with the findings of the CATT OCT Reading Center. This continuation grant proposal has two Specific Aims: Aim 1, to complete in all participants the two-year follow up of the original CATT grant application. Because enrolment of patients in the CATT trial was delayed, the period needed to complete the two year follow up must be extended beyond the time period proposed in the original plan. Aim 2, to perform an observational study for an additional 3-year follow up to investigate the long term effects of the study medications. Throughout the proposed studies the FPRC will provide reliable, timely, reproducible, and systematic grading of submitted color photographs and angiographic image materials for CATT. These activities will be similar to those provided in the first years of the CATT study. The FPRC will also continue to implement study specific materials and methods for reader, photographer, clinic coordinator, and ophthalmologist certification and training. FPRC activities will also support study goals as an image resource for recruitment, Study Group meetings, presentations and publications. RELEVANCE (See instructions): Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and most western countries. These studies of the relative effectiveness and safety of the two drugs under study will determine how patients with neovascular ("wet") AMD are treated in the future.