NEI Center Core Grants for Vision Research (P30)

描述（由申请人提供）：本提案的总体目标是为华盛顿大学（UW）的23名研究人员提供核心支持服务，他们共同拥有27项NEI ROI资助。核心支持服务旨在(1)提高威斯康星大学视觉科学家进行的研究的质量和数量；(2)促进不同专业领域的研究人员之间的合作；(3)允许已有的研究人员开展试点项目和探索新领域；(4)促进威斯康星大学视觉科学界的创新。除了NEI R01支持的研究项目的研究人员外，核心模块预计将促进其他14名研究人员的实验室视觉研究，这些研究人员的资金来自非NEI来源，其长期目标是帮助这些研究人员获得NEI ROI资助。在这14名研究人员中，核心资助的短期目标是帮助初级研究人员建立实验室并申请NEI ROI支持，并招募新的研究人员进行视觉研究。总的来说，华盛顿大学的视觉科学家们在视觉研究中跨越了非常广泛的领域，从研究分子在视觉中的作用到评估清醒行为的人类和非人类灵长类动物的视觉表现。威斯康星大学视觉科学家小组非常重视转化研究，在所有领域进行调查，旨在了解致盲疾病的机制和治疗和预防的发展。核心基金将支持三个模块，每个模块都由在视觉研究方面经验丰富的高技能研究科学家组成。细胞生物学服务和共享仪器模块提供显微镜，图像分析，组织准备和切片。分子生物学服务和共享仪器模块提供常规DNA分离和基因分型，单克隆抗体生产和免疫细胞化学。系统生物学服务和共享仪器模块提供计算机编程、磁共振成像、视网膜电图和视觉功能行为测试方面的技术协助。

DESCRIPTION (provided by applicant): The overall goal of this proposal is to provide core support services for 23 investigators at the University of Washington (UW), who together hold 27 NEI ROI grants. The CORE support services are designed (1) to enhance both quality and quantity of research conducted by UW vision scientists, (2) to facilitate collaborations between investigators with different areas of expertise, (3) to allow established investigators to conduct pilot projects and explore new areas, (4) to facilitate innovation within the UW vision science community. In addition to investigators with NEI R01 supported research programs, the Core Modules are anticipated to facilitate vision research in labs of 14 other investigators whose funding is from non-NEI sources with the long-term goal of helping these investigators obtain NEI ROI grant funding. Among these 14 investigators, the short term goals of the core grant are to assist junior investigators establish their labs and apply for NEI ROI support, and to recruit new investigators to vision research. Collectively, UW vision scientists span a very broad range of areas within vision research ranging from investigations of the roles of molecules in vision to assessment of visual performance in awake behaving human and non-human primates. There is a strong emphasis on translational research within the UW vision scientist group with investigation in all areas being targeted at understanding disease mechanisms and development of treatments and preventions for blinding conditions. The Core Grant will support three modules, each of which is staffed by highly skilled research scientists who are also experienced in vision research. The Cellular Biology Services and Shared Instrumentation Module offers microscopy, image analysis, and tissue preparation and sectioning. The Molecular Biology Services and Shared Instrumentation Module offers routine DNA isolation and genotyping, monoclonal antibody production, and immunocytochemistry. The Systems Biology Services and Shared Instrumentation Module offers technical assist with computer programming, magnetic resonance imaging, electroretinograms, and behavioral tests of visual function.