Vision Research Center (CORE) - P30

描述（由申请人提供）：获得独立国家眼科研究所（NEI）资助的研究人员将获得额外的共享支持，以提高他们自己和华盛顿大学进行视觉研究的能力。这种共同的支持将促进合作研究，并吸引科学家对视觉系统进行研究。将维持一个模块化的组织结构，每个模块专门用于一个特定的活动，这将是不切实际的或效率较低的支持一个单独的研究经费。每个模块将支持一项服务或资源，以增强或促进核心研究小组的研究工作，每个模块都有独立的资金来源。一些资源和服务将与非nei资助的合作者和新的视觉研究人员共享。初级研究人员也将有机会利用这些设施，以提高他们获得独立的NEI资助的能力。建议的模块包括：生物化学/免疫学（B/l），基因分型/表型（G/P），形态成像（M/l）和心理物理学/生理学（PIP）。研究领域包括视网膜和脉络膜疾病、角膜伤口愈合、角膜疾病、晶状体和白内障、青光眼、斜视、弱视、视觉处理和眼部发育。将涉及这些问题的具体学科包括：行为研究、生物化学、生物统计学、分子生物学、细胞生物学、蛋白质组学、免疫学、显微镜学、微生物学、形态计量学、神经生理学和病理学。该项目将阐明眼睛和视觉系统功能的基本机制，并将这些知识和其他信息应用于视力和眼科问题的解决。来自华盛顿大学和其他地方的研究人员之间的合作将得到促进。这项建议将提高个别研究项目拨款的有效性。

DESCRIPTION (provided by applicant): Investigators who have achieved independent National Eye Institute (NEI) funding will be provided with additional shared support to enhance their own and University of Washington's capability for conducting vision research. Collaborative studies will be facilitated, and scientists will be attracted to research on the visual system by the presence of this shared support. A modular organizational structure will be maintained, with each module devoted to a specific activity that would be impractical or less efficient to support on an individual research grant. Each module will support a service or resource that enhances or facilitates the research efforts of a CORE group of investigators, each having independent funding. Some sharing of resources and services with non-NEI-funded collaborators and with investigators new to vision research will occur. Junior researchers will also have access to these facilities to improve their ability to attain independent NEI funding. Proposed modules include: Biochemistry/Immunology (B/l), Genotyping/Phenotyping (G/P), Morphological Imaging (M/l), and Psychophysics/Physiology (PIP). Areas of investigation include retinal and choroidal diseases, corneal wound healing, corneal diseases, lens and cataract, glaucoma, strabismus, amblyopia, visual processing, and ocular development. Specific disciplines that will be brought to bear on these problems include: behavioral studies, biochemistry, biostatistics, molecular biology, cell biology, proteomics, immunology, microscopy, microbiology, morphometry, neurophysiology, and pathology. This project will elucidate basic mechanisms that underlie the function of the eye and the visual system and apply this knowledge and other information to the solution of problems in vision and ophthalmology. Collaboration among investigators from the University of Washington and elsewhere will be promoted. This proposal will improve the effectiveness of funding available on individual research project grants.