Sleep and Processing Traumatic Memory

描述(申请人提供)：睡眠似乎在重要方面有助于创伤后应激障碍或创伤后应激障碍的发展和维持，以及从创伤的不利影响中恢复和恢复。然而，关于睡眠和创伤后应激障碍之间的关系存在不确定性，以至于最近的文献中都表达了关于睡眠巩固与适应性处理创伤记忆的相反观点。这一探索性/发展性研究应用的目标是建立一种测试睡眠参数和创伤记忆处理之间关系的范例。如果成功，假说得到支持，这些程序将被应用于开发药物和其他干预措施，以增强睡眠的益处，并评估睡眠限制和睡眠中断的有害影响的阈值。在开发一种新的方法时，我们还将评估在晚上和早上进行书面叙事披露会议的效果，其中包括干预睡眠(评估白天和夜间的影响)或醒来的效果，包括其对睡眠、创伤后应激障碍症状和非特定痛苦的潜在影响。我们将利用受试者内部的交叉设计来确定，在影响习惯化和其他适应性情绪处理指数方面，带有睡眠干预的叙述性披露会议是否会比被清醒时段分隔的会议更有效。我们将确定哪些情绪处理指标对睡眠影响最敏感。我们还将评估干预性睡眠特征的影响，包括快速眼动连续性的测量。 公共卫生相关性：睡眠似乎对创伤后应激的恢复和预防很重要，睡眠中断会导致创伤后应激障碍。然而，关于睡眠在处理创伤记忆中的具体作用还存在争议。拟议的研究将开发一种解决这些不确定性的方法，这将对创伤后痛苦和创伤后应激障碍的治疗和预防产生影响。

DESCRIPTION (provided by applicant): Sleep appears to contribute in important ways to the development and maintenance of posttraumatic stress disorder or PTSD as well as to recovery from, and resilience to adverse effects of trauma. However, uncertainty regarding relationships between sleep and PTSD exists such that opposing views of sleep's role as consolidating versus adaptively processing trauma memories have both been recently expressed in the literature. The goal for this exploratory/developmental research application is to establish a paradigm for testing relationships between sleep parameters and processing trauma memories. If successful, and hypotheses are supported, the procedures will be applied to developing pharmacological and other interventions to enhance sleep's benefits, and to evaluate thresholds for detrimental effects of sleep restriction and disruption. In developing a novel approach we will also be evaluating the effects of written narrative disclosure sessions in the evening and morning with intervening sleep (overnight and daytime to evaluate for time of day effects) or wake, including its potential impact on sleep, PTSD symptoms, and non-specific distress. We will utilize a within subjects cross-over design to determine whether sessions of narrative disclosure with an intervening sleep period will be more effective than sessions separated by a wake period in effecting habituation and other indices of adaptive emotional processing. We will determine which indices of emotional processing are most sensitive to sleep effects. We will also evaluate the influence of characteristics of intervening sleep including measures of REM continuity. PUBLIC HEALTH RELEVANCE: Sleep appears to be important to recovery from and prevention of posttraumatic stress and disrupted sleep contributes to PTSD. There is controversy, however, about the specific role for sleep in processing traumatic memories. The proposed research will develop an approach for resolving these uncertainties that will have implications for treatment and prevention of posttraumatic distress and PTSD.