Cancer Center Support Grant

描述（由申请人提供）：本申请寻求更新CCSG资助希望之城综合癌症中心（COHCCC）。COHCCC汇集了来自希望之城医疗中心和贝克曼研究所34个部门的131名成员。该中心从NCI获得24，212，096百万美元（总计），从其他同行评审来源获得25，947，483百万美元，从非同行评审来源获得31，421，929百万美元，总资金为81，581，508百万美元。通过教师招聘，重组和重大的基础设施建设，COHCCC大大提高了其加速临床和转化癌症研究的能力。招募了72名新教师，包括48名临床研究人员和24名基础和人口研究科学家。癌症中心有五个项目：分子肿瘤学（MONC），发育癌症治疗（DCT），癌症免疫治疗（CI），血液肿瘤（HM）和癌症控制和人口科学（CCPS）。中心的成员资格已经磨练，以提高癌症的重点和准会员类别已创建的研究人员，其同行评审的潜力，癌症为重点的研究尚未发展。该应用程序请求支持10个共享资源：分析细胞学，分析药理学，生物信息学，功能基因组学/基因组测序，病理学，小动物成像，药物发现和结构生物学，调查研究，生物统计学，临床协议和数据管理。COHCCC准备在未来几年取得重大进展。我们的72名新的基础，人口和临床研究人员将继续引入新的想法，技术和研究重点领域，同时加强中心的创造性和创新环境。已经建立了重要的基础设施和其他资源，以促进将发现转化为新的癌症治疗，诊断测试和其他干预措施的快速发展，这些干预措施将帮助癌症患者以及有恶性肿瘤风险的个人。最后，该机构的整体配置及其在领导，计划调整，发展和权威方面的行政能力得到了增强，使癌症中心将更好地响应其成员，并利用他们的集体能量和创造力。该提案表明，COHCCC为实现其使命建立了一个坚实的结构，比以往任何时候都更强大，更可持续。

DESCRIPTION (provided by applicant): This application seeks renewed CCSG funding for the City of Hope Comprehensive Cancer Center (COHCCC). The COHCCC brings together 131 Members from 34 Departments in the City of Hope Medical Center and the Beckman Research Institute. The Center receives $24,212,096M (Totals) from NCI, $25,947,483M from other peer-reviewed sources, and $31,421,929M from non-peer-reviewed sources, for a total of $81,581,508M in overall funding. Through faculty recruitment, reorganization, and significant infrastructure development, the COHCCC has greatly enhanced its ability to accelerate clinical and translational cancer-focused research. Seventy-two new faculty have been recruited, including 48 clinical investigators and 24 basic and population research scientists. The Cancer Center has five Programs: Molecular Oncology (MONC), Developmental Cancer Therapeutics (DCT), Cancer Immunotherapeutics (CI), Hematologic Malignancies (HM), and Cancer Control and Population Sciences (CCPS). Center membership has been honed to sharpen cancer focus and an Associate Member category has been created for investigators whose potential for peer-reviewed, cancer-focused research is yet developing. This application requests support for ten Shared Resources: Analytical Cytometry, Analytical Pharmacology, Bioinformatics, Functional Genomics/Genomic Sequencing, Pathology, Small Animal Imaging, Drug Discovery and Structural Biology, Survey Research, Biostatistics, and Clinical Protocol and Data Management. The COHCCC is primed to make significant advances in the coming years. Our 72 new basic, population and clinical research recruits will continue to introduce new ideas, technologies, and areas of research focus while enhancing the creative and innovative environment of the Center. Significant infrastructure and other resources have been created to facilitate the translation of discoveries to the rapid development of new cancer treatments, diagnostic tests, and other interventions that would aid people with cancer, as well as individuals at risk for malignancy. Finally, the overall configuration of the institution and its administrative capabilities in terms of leadership, programmatic alignment, development, and authority that have been augmented so that the Cancer Center will be more responsive to its members and to harness their collective energies and creativity. This proposal documents that the COHCCC has built a solid structure for achieving its missions and is stronger and more sustainable than it has ever been.