Inflammasome function in gastrointestinal immunity and inflammation

肠道中的免疫系统提供了抵御微生物的重要防御系统。如果这些防御措施无效，我们就会受到感染，导致胃肠炎，这是第三世界死亡的主要原因，也是发达国家住院的主要原因。相反，过度或不适当地激活这些防御系统会导致炎症性疾病。该项目将研究肠道中的微生物检测，旨在发现治疗胃肠道感染和炎症的新的、更有效的方法。

The immune system in the gut provides a vital defence against microbes. If these defences are ineffective we become infected leading to gastroenteritis, a major cause of death in the third world and hospitalisation in developed countries. Conversely, excessive or inappropriate activation of these defences can cause inflammatory disease. This project will investigate microbial detection in the gut, and aims to discover new, more effective ways to treat gastrointestinal infection and inflammation.