Inflammasome function in neutrophils

作为第一个募集的细胞，中性粒细胞直接对抗感染的保护性反应，但也可以介导炎性疾病的破坏性反应。该项目将通过检查中性粒细胞中特定的炎症促进分子通路（炎症介质）来确定两种情况下驱动嗜中性粒细胞依赖性炎症的机制。这项研究将有助于更好地了解炎症，并可能为治疗炎症性疾病提供治疗方法。

As the first recruited cells, neutrophils direct protective responses against infection, but can also mediate destructive responses in inflammatory disease. This project will determine mechanisms driving neutrophil-dependent inflammation in both settings, by examining a specific inflammation-promoting molecular pathway (the ïinflammasomeÍ) in neutrophils. This research will lead to a better understanding of inflammation, and may suggest therapeutics for treating inflammatory disease.