Training in Multi-Scale Analysis of Biological Structure and Function

描述（由申请人提供）：为了培养能够跨越医学、生物、物理和工程科学学科界限的跨学科研究科学家骨干，拟议的研究培训计划将支持10名博士预科学生在加州大学圣地亚哥分校新成立的跨学科多尺度生物学博士学位专业进行博士学习的第二和第三年。该专业的学生属于生物科学系、健康科学系、物理科学系和雅各布斯工程学院五个已建立且排名靠前的研究生课程之一（生物工程、生物医学科学、生物科学和神经科学）。培训课程的一个独特之处是六门专业实践实验课程，涉及专业技术（包括质谱、光学和电子显微镜、磁共振成像和高性能计算），用于测量和分析从分子到整个生物组织的多个尺度的生物结构和功能。对生物结构和功能的多尺度分析的科学关注反映了现代生物医学科学的基本挑战，以及来自18个部门的37名项目教师（包括3名HHMI调查员和1名MAS成员）的优势

DESCRIPTION (provided by applicant): To help train a cadre of interdisciplinary research scientists who can cross disciplinary boundaries between medical, biological, physical and engineering sciences, the proposed research training program will support ten pre-doctoral students during their second and third years of doctoral study in a newly established interdisciplinary Ph.D. degree Specialization in Multi-Scale Biology at UCSD. Students in the specialization belong to one of five established and highly ranked graduate programs (Bioengineering, Biomedical Sciences, Biological Sciences and Neurosciences) from the Divisions of Biological Sciences, Health Sciences, Physical Sciences and the Jacobs School of Engineering. A unique feature of the training curriculum is six specialized hands-on laboratory courses in specialized technologies (including mass spectrometry, light and electron microscopy, magnetic resonance imaging and high-performance computing) for measuring and analyzing biological structures and functions across multiple scales of biological organization from molecular to whole organism. The scientific focus on multi-scale analysis of biological structure and function reflects a fundamental challenge of modern biomedical science and the strengths of the 37 program faculty (with three HHMI Investigators and one member of the MAS) from 18 departments (Eng., Biological Sciences., Physical Sciences and Health Sciences, Schools of Medicine or Pharmacy, with two new faculty from the Skaggs School of Pharmacy and Pharmaceutical Sciences) in developing and applying novel approaches from biochemistry, cell biology, biophotonics, microscopy, tissue engineering, imaging and computational modeling to integrative problems in biomedicine spanning the molecular to whole organism scales. The dual-mentored training program provides outstanding interdisciplinary graduate research opportunities in these areas, especially in relation to human genetics, development and cancer, diseases and disorders of the nervous, cardiovascular, and musculoskeletal systems, diagnostics and therapeutics. The graduate training program also provides a highly interdisciplinary training environment and a wealth of activities to promote new interdisciplinary collaborations and interactions. RELEVANCE: Most important scientific challenges of modern biomedicine require a detailed understanding of how biological processes at the molecular scale give rise to functions at the levels of the cell, tissue, organ and whole body. This program trains graduate students at the interfaces between engineering, physical sciences, biological sciences and health sciences to apply modern technologies to these challenges.