Administrative and Biostatistics Core

这项计划项目拨款(PPG)建立在调查人员在理解 抗HIV的中和抗体和CD8+T细胞反应，新型纳米粒递送的发展 添加并将这些努力转化为新开发的BLT(骨髓、肝脏、胸腺) 人源化的HIV感染小鼠模型。对此POL的成功至关重要的是一名行政和 生物统计学核心设施不仅在协调这两个方面提供科学和行政领导 项目和组成这项工作的三个核心，但也协调采购、存储和 从接种疫苗和挑战的人源化小鼠中检索样本，用于每个单独的项目 推动研究，确保这些有价值的样品的加工和储存质量，保持 数据库，以支持该方案的目标，并提供生物统计学支持，使整合成为可能 为组成这一POL的高度互补性的项目收集临床、免疫学和病毒学数据。 这些努力将并行进行，但以协调和高度整合的方式进行，以便 来自每一项努力的信息，不断地指导和告知其他人。具体来说，我们建议 行政和生物统计核心将： 1.对赠款的各个方面进行科学的领导和项目管理。 2.提供行政和财务监督。 3.为项目的各个方面提供生物统计学支持。 4.招募科学顾问委员会，并主办年度会议。 5.维护BLT小鼠的临床、免疫学和病毒学数据的数据库。

This Program Project Grant (PPG) builds on the investigators strong track records in understanding neutralizing antibody and CD8+ T cell responses against HIV, the development of novel nanoparticle delivery appraoches and translates these efforts into a newly developed BLT (bone marrow, liver, thymus) humanized mouse model of HIV infection. Critical to the success of this POl is an Administrative and Biostatistics Core facility provide not only scientific and administrative leadership in coordinating the two Projects and three Cores that make up this effort, but also to coordinate the acquisition, storage, and retrieval of samples from vaccinated and challenged humanized mice for each of the individual projects that fuel the research, to insure quality processing and storage of these valuable samples, to maintain a database to support the goals of this program, and to provide biostatistical support that will allow integration of clinical, immunologic and virologic data for the highly complementary projects that make up this POl. These efforts will occur in parallel, but in a coordinated and highly integrated fashion that allows for information from each of the efforts to continually guide and inform the others. Specifically, we propose that the Administrative and Biostatistics Core will: 1. Provide scientific leadership and project management for all aspects of the grant. 2. Provide administrative and financial oversight. 3. Provide biostatistical support for all aspects of the program. 4. Recruit a Scientific Advisory Board and host an annual meeting. 5. Maintain a database of clinical, immunological, and virological data from BLT mice.