Mutant Mouse Resource and Research Center

描述（由申请人提供）：基因工程小鼠（转基因，敲除和敲入）已成为几乎所有医学领域的宝贵。由于GEM对了解人类发育和疾病以及创造改进的药物和治疗方法的重要性，在过去十年中已经创造了数万种GEM。MMRRC为生物医学界提供了一个独特的储存库服务，用于进口，储存和分发大量的GEM作为生物医学界的资源。自1999/2000年MMRRC网络作为一个羽翼未丰的储存库开始以来，它已发展成为生物医学界的主要资源，其能力和小鼠品系和胚胎干细胞（ES）的综合库存超过了全球其他小鼠储存库的能力。本提案的总体目标是继续和扩大密苏里州大学突变小鼠区域资源中心（MMRRC）的这些功能和能力，为生物医学研究人员提供研究所需的小鼠模型和相关试剂。

DESCRIPTION (provided by applicant): Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community. Since the MMRRC Network began as a fledging repository in 1999/2000, it has evolved into a major resource for the biomedical community with capabilities and a combined inventory of mouse lines and embryonic stem (ES) cells that exceeds the capacity of other mouse repositories worldwide. The overall goal of this proposal is to continue and expand these functions and capabilities of the Mutant Mouse Regional Resource Center (MMRRC) at the University of Missouri to provide biomedical investigators with the mouse models and related reagents they require for their research.