NIDCD Core for Clinical Research and Care

NIDCD临床研究和护理核心支持以下NIDCD项目： 1 Z 01-DC-000016-19 NF-kappaB在影响人类交流的神经系统疾病的分子发病机制和治疗中的作用 1 Z 01 DC 000031 -17人体功能性神经影像学研究 1 Z 01 DC 000039 -15综合征型和非综合征型听力障碍基因的鉴定 1 Z 01 DC 000046 -15人类交流障碍的遗传学研究 1 Z 01 DC 000057 -14脑成像和建模 1 Z 01 DC 000060 -12人类遗传性耳聋的分子分析 1 Z 01 DC 000064 -12听力和平衡障碍的临床分析 1 Z 01-DC-000073-5头颈癌中信号和转录因子网络的相互作用 1 Z 01-DC-000074-5头颈癌的基因组学和蛋白质组学 核心支持的NIDCD协议包括： T-DC-0005注意力测量研究 Oh 93-DC-0016 -非综合征型遗传性听力障碍基因定位：印度/巴基斯坦方案 92-DC-0178 -言语运动控制和语言处理的功能性神经成像研究 97-DC-0057 -口吃的非参数和参数连锁研究 97-DC-0180 -人类遗传性听力障碍的遗传分析 00-DC-0073-遗传性听觉处理缺陷的识别 00-DC-0176 -音调性耳聋的遗传学研究 01-DC-0099 -NIDCD头颈外科分支临床研究方案评价 01-C-0104 -一项在复发性或转移性头颈部鳞状细胞癌患者中进行的前体蛋白酶体抑制剂PS-341和放疗联合治疗的I期研究。 01-DC-0228 -前庭水管扩大（伊娃）相关听力损伤的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 01-DC-0230 -味觉缺陷的研究 02-DC-0008 -使用C-11雷氯必利和PET评估发育性口吃中突触前和突触后多巴胺功能 05-DC-0238 -睡眠延迟和恢复睡眠对言语、语言和其他高级认知功能的影响：一项联合EEG和fMRI研究 06-DC-0218 -Tintin的神经建模和脑成像 08-C-0071 -硼替佐米和西妥昔单抗联合或不联合顺铂放疗治疗晚期头颈癌患者的I期研究 10-D-180 -雷帕霉素新辅助治疗晚期头颈癌的初步研究 NIDCD临床研究和护理核心每年支持2，500 - 5，000次门诊评估。核心耳鼻喉科医生执行100例重大手术病例。在高级临床实习期间，工作人员指导医学生。如参考书目所示，合作研究为几份已出版的手稿做出了贡献。

The NIDCD Core for Clinical Research and Care supported the following NIDCD projects: 1 Z01-DC-000016-19 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 Z01 DC000031-17 Functional Neuroimaging Studies in Humans 1 Z01 DC000039-15 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 Z01 DC000046-15 Genetic Studies of Human Communications Disorders 1 Z01 DC000057-14 Brain Imaging And Modeling 1 Z01 DC000060-12 Molecular Analysis Of Human Hereditary Deafness 1 Z01 DC000064-12 Clinical Analysis Of Disorders Of Hearing And Balance 1 Z01-DC-000073-5 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 Z01-DC-000074-5 Genomics and Proteomics of Head and Neck Cancer The NIDCD protocols supported by the core include: T-DC-0005 Studies of Measures of Attention Oh93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 92-DC-0178 - Functional Neuroimaging Studies of Speech Motor Control and Language Processing 97-DC-0057 - Non-parametric and parametric Linkage Studies of Stuttering 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 00-DC-0073- Identification of Hereditary Auditory Processing Defiicts 00-DC-0176 - Genetic Studies of Tune Deafness 01-DC-0099 - Evaluation for NIDCD Head and Neck Surgery Branch Clinical Research Protocols 01-C-0104 - A Phase I Study of Concomitant Therapy with Preoteasome Inhibitor PS-341 and Radiation in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment Associated with Enlarged Vestibular Aqueducts (EVA) 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 01-DC-0230 - Studies in the Deficits in the Sense of Taste 02-DC-0008 - Assessment of pre- and post-synaptic dopamine function in developmental stuttering using C-11 raclopride and PET 05-DC-0238 - Effects of Sleep Deprivation and Recovery Sleep on Speech, Language and Other Higher Cognitive Functions: A Combined EEG-fMRI Study 06-DC-0218 - Neural Modeling and Brain Imaging of Tinnitus 08-C-0071 - Phase I Study of Bortezmib and Cetuximab without or with Cisplatin with Radiation therapy for Patients with Advanced Head and Neck Cancer 10-D-180 - Pilot Study of neoadjuvant rapamycin for patients with advanced head and neck cancer The NIDCD Core for Clinical Research and Care supports 2,500-5,000 outpatient clinic evaluations per year. Core otolaryngologists perform 100 major surgical cases. Staff mentor medical students during senior clinical clerkships. Collaborative studies resulted in contributions to several published manuscripts as indicated in the Bibliography.