Understanding and preventing breast cancer disparties in Latinas

描述（由申请人提供）：乳腺癌是美国西班牙裔女性中最常见的癌症。西班牙裔白人的乳腺癌发病率（83.5 / 10万）低于非西班牙裔白人（147.3 / 10万）；然而，随着西班牙裔女性接受美国主流文化的做法，她们患乳腺癌的风险增加了。此外，西班牙裔妇女患预后不良的乳腺癌的风险增加。这项PSO应用的首要主题是了解和预防乳腺癌的前体，并减少拉丁美洲人的乳腺癌发病率和死亡率。这将在多个层面上进行，并将涉及多个学科的研究人员。精心设计了一些项目，以促进对拉丁美洲人乳腺癌的了解和预防。了解拉美裔人群乳腺癌的发病前因，了解拉美裔人群乳腺癌的类型，制定并实施全面的筛查方案，提高拉美裔人群乳腺癌的早期发现机会，是本PSO应用的长期目标。我们的短期目标是：

DESCRIPTION (provided by applicant): Breast cancer is the most common cancer among Hispanic women in the United States (US). The incidence of breast cancer among Hispanics (83.5 per 100,000) is lower than that among non-Hispanic Whites (147.3 per 100,000); however, as Hispanic women adopt the practices of mainstream US culture, their risk for breast cancer increases. Further, Hispanic women are at increased risk for breast cancers with poor prognosis. The overarching theme of this PSO application is to understand and prevent pre-cursors of breast cancer and to reduce breast cancer morbidity and mortality among Latinas. This will be done at multiple levels and will engage researchers across several disciplines. Projects have been carefully designed to contribute understanding to and preventing breast cancer in Latinas. It is the lonq-term goal of this PSO application to understand the antecedents of breast cancer in the Latina population, to understand the types of breast cancer found in the Latina population, and develop and implement a comprehensive program of screening to increase the opportunities for early breast cancer detection among Latinas. Our short-term obiectives are to: 1. Increase breast cancer screening among age-eligible Latinas; 2. Understand the processes by which ancestry, BMI, inflammation, and breast cancer are related in Latinas 3. To understand aspects of the etiology of poor prognosis breast cancers by identifying risk factors related to triple negative (TN) and HER-2-overexpressing (H2E) tumors, which are more commonly found in Latinas compared to non-Hispanic whites 4. To understand the role of ancestry in breast cancer antecedents and incidence among Latinas. 5. To explore expression of genes involved in tumor-related pathways signaling. This application is committed to a comprehensive multi-level approach to reducing health disparities. Its projects range from the biologic and genetic to the social context within which people live. Through its four projects and cores, the proposed Center will cover a myriad of aspects of breast cancer, from biological processes and genetic pathways to individual determinants and social determinants of breast cancer.