Lifestage Exposures and Adult Disease

密歇根大学-NIEHS中心是一个新的实体，它将把基础科学家和转化科学家聚集在一起，形成一个合作伙伴关系，重点是“生命暴露与成人疾病”这一主题。其使命是利用新的多学科方法促进转化性研究，通过涉及生命脆弱阶段表观遗传修饰的机制来了解环境暴露对成人慢性疾病的影响。这是一个为期两年的规划进程的高潮，该进程建立了协作(包括与CTSA的主要伙伴关系)，并作为事实上的初步中心发挥作用。坚实的研究基础包括针对各种环境毒物的项目、跨越年龄段的大量队列研究(和相关的生物信息库)、特定疾病的研究中心(和相关的组织库)以及表观遗传机制的基础研究。在这份修订后的申请中，研究人员保留了他们公认的优势，同时增加了他们的重点，将他们的目标领域从6个减少到3个，每个领域现在都与一个具有高级领导层的研究团队相关，他们的成员减少了近40%。研究人员的研究团队将把重点放在“表观遗传调控”、“氧化应激”和“内分泌干扰物”上，这些子主题建立在该中心优势的基础上。这项工作首先强调四种疾病，这四种疾病在研究人员目前的研究组合中得到了很好的代表(哮喘、早产、代谢综合征和神经退行性疾病)，随着中心的成长和成熟，可以灵活地扩展。该中心将赞助研讨会；利用主要机构杠杆作用的试点项目计划；杰出的年轻中心科学家；以及对更广泛的科学界和非科学界的外联和教育。这项研究将由一个行政核心和五个与暴露、生物反应、综合健康科学、环境统计和生物信息学有关的服务核心推动。综合健康科学核心将管理一个基于网络的门户，提供一个创新的互动信息亭，用于获取有关资源、核心设施和研究工具的关键信息。核心教员还将提供“翻译服务”，为翻译研究的设计和使用他们的生物信息库和核心设施提供咨询。经修订的社区外联和教育核心将与调查员和利益攸关方咨询委员会合作，开展范围更广的活动。中心的管理将由一个积极的执行委员会和在外部咨询委员会任职的杰出科学家提供便利。

The University of Michigan-NIEHS Center is a new entity that will bring together basic and translational scientists into a partnership focused on the theme of "Lifestage Exposures and Adult Disease". The mission is to promote translational research using novel multi-disciplinary approaches to understand the impact of environmental exposures on adult chronic disease through mechanisms involving epigenetic modifications during vulnerable stages of life. This is the culmination of a 2-year planning process of building collaborations (including a major partnership with the CTSA) and functioning as a de-facto preliminary Center. The robust base of research includes projects addressing a variety of environmental toxicants, a large portfolio of cohort studies (and associated biorepositories) spanning the age spectrum, disease-specific research Centers (and associated tissue banks), and basic research on epigenetic mechanisms. In this revised application, the investigators retain their recognized strengths while increasing their focus, decreasing their targeted areas from 6 to 3, each now associated with a Research Team with senior leadership, and decreasing their membership by almost 40%. The investigators' Research Teams will focus on "Epigenetic Regulation", "Oxidative Stress" and "Endocrine Disruptors", subthemes that build off of the Center's strengths. The work starts with an initial emphasis on four diseases well-represented in the investigators' current research portfolio (asthma, prematurity, metabolic syndrome, and neurodegenerative disease), with the flexibility to expand as the Center grows and matures. The Center will sponsor seminars; a Pilot Project Program that capitalizes on major institutional leveraging; outstanding young Center scientists; and outreach and education to the broader scientific and lay community. The research will be facilitated by an Administrative Core and five service cores related to Exposures, Biological Responses, Integrative Health Sciences, Environmental Statistics and Bioinformatics. The Integrated Health Sciences Core will manage a web-based portal providing an innovative interactive kiosk for obtaining critical information on the resources, Core facilities, and tools for research. Core faculty will also provide "translational services", for consulting on the design of translational research and use of their biorepositories and Core facilities. A revised Community Outreach and Education Core will work with the investigators and a Stakeholder Advisory Board to engage in an enhanced range of activities. Administration of the Center will be facilitated by an active Executive Committee and outstanding scientists serving on the External Advisory Committee.