The Role of Hippo Pathway in Liver Regeneration

描述（由申请人提供）：肝脏疾病是美国十大死亡原因之一。肝脏非凡的再生能力对于理解导致发育缺陷、急性和慢性肝病以及肝癌发生的机制至关重要。在防止肝细胞凋亡的同时刺激肝细胞增殖对肝脏的再生过程至关重要。最近我们发现一种肿瘤抑制通路对肝细胞分裂和死亡有强有力的影响。我们的长期目标是确定健康和疾病中肝脏再生的细胞机制，并将这些发现应用于开发改进的肝脏疾病治疗方法。为此，我们有独特的能力来解决这一应用的目标，即揭示导致新型肿瘤抑制因子对肝脏产生深远影响的机制。本研究的中心假设是：肿瘤抑制因子通过控制肝细胞生长因子通路来控制肝脏大小。在研究结束时，我们将更好地了解肝细胞的生长和死亡。这将有助于开发许多肝脏疾病的治疗方法，如肝移植、肝硬化、急性和慢性肝炎。

DESCRIPTION (provided by applicant): Liver diseases are among the 10 leading causes of death in the United States. The liver's extraordinary regenerative capacity is critical to understanding the mechanisms leading to developmental defects, acute and chronic liver diseases, and liver carcinogenesis. Stimulation of hepatocyte proliferation while preventing apoptosis is essential to the liver's regenerative process. Recently we uncovered a tumor suppressor pathway has potent effects upon liver cell division and death. Our long range goal is to define the cellular mechanisms underlying liver regeneration in health and disease and to apply these findings to developing improved therapies for liver disease. To that end, we are uniquely capable to address the objectives of this application, which are to uncover the mechanism that leads to the novel tumor suppressors' profound effects upon the liver. The central hypothesis of this proposal is that: The tumor suppressor controls liver celgrowth factor pathway in controlling liver size. At the end of the study we will better understand the growth and death of liver cells. This will help develop treatment for many liver diseases such as liver transplantation, cirrhosis, acute and chronic hepatitis. Project Narrative: The objectives of this study are to uncover a newly recognized very potent molecular system that controls the growth and death of the liver cells. Unlocking how this pathway works will help develop treatment for many liver diseases such as liver transplantation, cirrhosis, acute and chronic hepatitis.