"Sleep Medicine Neurobiology and Epidemiology"

描述（由申请人提供）：该培训基金培养睡眠、生理学和流行病学领域的医生和博士后研究人员，以解决严重影响我们社会整体健康的问题。科学研究和发现有很大的需要和机会。风险和疾病检测/管理工作不发达，睡眠医学的基础科学（睡眠生理学和昼夜节律）在生物学，神经网络和脑生理学的功能理解方面存在重大差距，以便为未来的治疗和预防工作提供信息。一个障碍是缺乏基础研究和面向患者的研究人员。该项目由退伍军人医疗中心睡眠障碍研究中心负责人金曼·p·斯特罗尔负责。睡眠障碍研究中心现在在医学院和其他四家克利夫兰学术医疗中心开展培训和研究项目。他和一个指导委员会（泰德·迪克博士）。（Richard Martin MD和Mark Chance博士）批准项目的录取，并使用形成性的学员委员会评估和组合技术来监控学员的进展。展望未来，增加的维度是生理和生物物理系正式的系统生物学和生物信息学硕士和博士课程。16位教师导师为“培训师”，4位职业生涯早期获奖教师为“初级培训师”；睡眠或基础科学领域的其他资深教员作为实习生委员会成员参加。教师代表六个系，每个系都对睡眠、昼夜生物学、睡眠流行病学和/或临床研究有固有的兴趣。该计划要求两名有足够资源进行高级培训的研究生培训生和两名研究生培训生。我们提供临床科学硕士学位课程（CTST临床研究学者计划）和系统生物学博士博士后学员的选择。对所有受训者来说，本质是个性化、监督式的研究性训练；但是所有的受训者都要参加教学工作，包括睡眠科学和医学，接触其伦理、法律和社区问题，以及职业发展。对于博士预科生，学位授予部门决定课程作业和论文进度，睡眠医学培训项目的临床医生是博士委员会的成员之一。博士后受训者也有一个培训委员会来评估进度和指导。所有受训者都有一个工作组合，并对进展进行自我评估，这是每两年进行一次评估的基础。每周都有研讨会，每年都有外部顾问和教师参加。现在医学、儿科学、生理学和生物物理学、神经科学、计算机科学、生物统计学和流行病学之间有很强的相互作用。睡眠医学项目现在被公认为是病例临床转化科学合作研究基础设施的一部分。

DESCRIPTION (provided by applicant): This training grant produces physician and post-doctoral investigators in the fields of sleep, its physiology and epidemiology to address problems that substantially effect the general health of our society. There are significant needs and opportunities for scientific research and discovery. Risk and disease detection/management efforts are poorly developed, and the basic science of sleep medicine (sleep physiology and circadian rhythm) has major gaps in functional understanding of biology, neural networks, and brain physiology in order to inform future treatments and prevention efforts. One barrier is a paucity of investigators in basic- and patient-oriented research. The program is managed by Kingman P. Strohl, who heads the Center for Sleep Disorders Research at the VA Medical Center. The Center for Sleep Disorders Research now reaches training and research programs in the School of Medicine and four other Cleveland academic medical centers. He and a steering committee (Ted Dick, PhD., Richard Martin MD, and Mark Chance PhD) approves admission to the program and monitors trainees' progress using formative trainee committee assessment and portfolio techniques. Looking forward, the added dimension is a formal Systems Biology and Bioinformatics M.S. and Ph.D. curriculum in the Department of Physiology and Biophysics. Sixteen faculty mentors are "trainers", with four early career awardees faculty as "junior trainers"; other senior faculty members in sleep or basic science participate as members of the trainee committee. Faculty represent six departments and each has an inherent interest in sleep, circadian biology, sleep epidemiology, and/or clinical investigation. The program requests two post-graduate trainees with sufficient resources to pursue advanced training and two graduate trainees. We provide options for a Master's Degree programs in Clinical Science (the CTST Clinical Research Scholars Program) and in Systems Biology for MD post-doctoral trainees. For all trainees the essence is individualized, supervised research training; but all trainees meet to engage in didactic work encompassing sleep science and medicine, exposure to its ethical, legal, and community issues, and career development. For pre-doctoral trainees, the degree-granting department determines course work and thesis progress, with a clinician from the Sleep Medicine Training Program as one member of the Ph.D. committee. Post-doctoral trainees also have a training committee which assesses progress and mentorship. All trainees maintain a portfolio of work with self-assessments of progress that forms the basis of bi-annual assessments. There are weekly seminars and an annual retreat of the group with outside advisors and faculty. A strong interaction now occurs among Medicine, Pediatrics, Physiology and Biophysics, Neuroscience, Computer Sciences, and Biostatistics and Epidemiology. The Sleep Medicine program is now a recognized as a part of the Case Clinical Translational Science Collaborative research infrastructure.