用于治疗菌血症的工程血管内导管-猫眼课题宝

用于治疗菌血症的工程血管内导管

批准号：

8676368

负责人：

JUN F LIANG

金额：

$18.75万

依托单位：

STEVENS INSTITUTE OF TECHNOLOGY

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-04-10 至 2016-03-31

来源：

https://reporter.nih.gov/project-details/8676368

关键词：

Adhesions Affect Animal Model Animals Antibiotic Resistance Antibiotics Autolysis Bacteremia Bacteria Blood Vessels Catalysis Catheters Cell membrane Cells Charge Chemistry Clinical Complication Critical Illness Devices Diagnosis Effectiveness Engineering Excision Exhibits Feedback Genetic Goals Hemodialysis Heparin Hospitalization Hour Hydrolysis Hydrophobicity Image Implantable venous access port Incubated Infection Infection prevention Life Mechanics Methods Modification Morbidity - disease rate Nature Patients Peripheral Phase Phospholipids Polyethylene Glycols Property Research Resistance Resistance Process Silicon Site Staphylococcus aureus Surface Suspension substance Suspensions Testing Time Venous Work antimicrobial bactericide base catalyst catheter related infection controlled release cost design engineering design methicillin resistant Staphylococcus aureus mutant prevent public health relevance

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中文摘要

翻译

描述（由申请人提供）：用于治疗菌血症的工程血管内导管大多数患者在住院期间的某个时间接受血管内导管置入，随后的感染是与血管内装置相关的最常见并发症，随后的菌血症可能是高度病态的，通常是致命的后果。在本项目中，我们将把相界催化原理应用于导管设计，并在动物模型上测试工程血管内导管预防感染和治疗菌血症的能力。

英文摘要

DESCRIPTION (provided by applicant): Engineered Intravascular Catheters for the Treatment of Bacteremia Most patients undergo intravascular catheter placement at some time during their hospitalization, Ensuing infection is the most common complication associated with intravascular devices and subsequent bacteremia can be a highly morbid and oftentimes lethal consequence. In this project, we will apply the principle of phase-boundary catalysis in catheter design and test ability of engineered intravascular catheters in preventing infections and treatment of bacteremia on animal models.

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