Designing Research Training for Rwandans in Emerging HIV & Drug Therapy

描述(由申请人提供)：为卢旺达人设计针对新出现的艾滋病毒和CART相关心血管、糖尿病和代谢并发症的研究培训卢旺达的人类免疫缺陷病毒(HIV)治疗方案非常成功，有资格接受联合抗逆转录病毒疗法(CART)的90%的人口可以获得国家艾滋病毒治疗服务。随着卢旺达努力成为一个中等收入国家，它正在经历向发展的快速过渡，人口老龄化、城市化、肥胖率可能更高，并可能受到两种不同的非传染性疾病流行的影响，以及艾滋病毒和抗逆转录病毒治疗的影响。尽管与艾滋病毒感染和CART治疗相关的代谢、心血管和糖尿病并发症的数据有限，但由于艾滋病毒和CART相关的代谢、心血管和糖尿病并发症的负担，该国的疾病负担正在逐渐增加。在这次规划的科研培训计划中，我们的目标是加强院校间的科研培训 我们与卢旺达妇女平等获得护理和治疗机构(WE-ACTx卢旺达)(申请机构)、基加利费萨尔国王医院和卢旺达国立大学建立了伙伴关系，与耶希瓦大学阿尔伯特·爱因斯坦医学院合作，利用卢旺达人的研究能力，解决与艾滋病毒和购物车相关的新出现的代谢、糖尿病和心血管并发症，包括最近描述的“营养不良”糖尿病这一实体，在存在艾滋病毒感染和购物车的情况下尚未对其进行研究。我们的第二个目标是使卢旺达申请者和他们的爱因斯坦合作者能够巩固关系，评估实施相关研究培训计划所需的科学和基础设施需求，确定潜在的受训者和卢旺达必要的员工发展，以便在两年的规划期后应用和实施成功的5年艾滋病毒研究培训计划(HRTP)。我们预计将开展以下工作：1)评估实施5年期HRTP所需的卢旺达科研培训需求和基础设施的可用性和差距；2)利用KFH、K远程医疗设施就艾滋病毒和ART-心血管、糖尿病和代谢并发症进行爱因斯坦教员的互动电话会议演示；3)参观爱因斯坦教员的研究地点和卢旺达学员的培训设施，学习和欣赏各种研究培训环境和计划，以计划未来5年HRTP的相关研究培训；4)开发包括短期和长期培训计划在内的5年期HRTP的申请。这些活动将利用卢旺达政府和卫生部的任务，提高卢旺达科学家和临床医生的可获得性和能力，并加强机构能力。因此，这些规划赠款活动将有助于更好地了解研究培训的要求，以促进强有力和连贯的爱因斯坦-卢旺达机构合作。

DESCRIPTION (provided by applicant): Designing Research Trainings for Rwandans in Emerging HIV- and cART- associated Cardiovascular, Diabetes and Metabolic Complications Treatment program for human immunodeficiency virus (HIV) in Rwanda is highly successful, with national HIV treatment services available to 90% of the population eligible for combination antiretroviral therapy (cART). As Rwanda strives to become a middle-income country, it is undergoing rapid transition to development with increasing aging population, urbanization, potential higher rates of obesity, and will potentially be affected by two separate epidemics of non- communicable diseases and effects HIV and ART treatment. Although data are limited on metabolic, cardiovascular and diabetes complications associated with HIV infection and treatment with cART, the country's disease burden is gradually increasing due the burden of HIV- and cART- associated metabolic, cardiovascular and diabetes complications. In this planning research training program, our goal is to strengthen inter-institutional research training partnerships for our institutions of Women's Equity in Access to Care and Treatment (WE-ACTx Rwanda) (applicant institution), King Faisal Hospital, Kigali and National University of Rwanda to collaborate with Albert Einstein College of Medicine, Yeshiva University to leverage research capacity for Rwandans to address emerging HIV- and cART-associated metabolic, diabetes and cardiovascular complications including the recently described entity of "malnutrition" diabetes which is unstudied in the presence of HIV- infection and cART use. Our second goal is to enable Rwandan applicants and their Einstein collaborators to solidify relationships, assess scientific and infrastructure needs required to implement relevant research training program, identify potential trainees and the necessary staff development in Rwanda to apply and implement a successful 5-year HIV Research Training Program (HRTP) after 2- years of planning period. We envisage to carry out the following: 1) assess availability and gaps for scientific research training needs and infrastructure in Rwanda that will be required to implement the 5-year HRTP; 2) carry out interactive Teleconference presentations by Einstein faculty using KFH, K Telemedicine facilities on HIV- and ART- cardiovascular, diabetes and metabolic complications; 3) visit out Einstein faculty's research sites and training facilities by Rwandan trainees to study and appreciate various research training settings and programs to plan relevant research trainings for the future 5-year HRTP; 4) develop an application for the 5-year HRTP that will include short-term and long-term training programs. These activities will leverage the Government of Rwanda (GoR) and Ministry of Health (MoH) mission to improve availability of, and capacity of Rwandan scientists and clinicians, and to reinforce institutional capacity. Thus, these planning grant activities will contribute to greater understanding of the requirements for research trainings to foster strong and coherent Einstein-Rwandan institutional collaborations.