Building Capacity for Cardiometabolic Outcomes Research

描述(由申请人提供)：Monika M.Safford，医学博士，阿拉巴马大学伯明翰分校(UAB)医学副教授，在那里她在观察性和实施性研究方面建立了成功的研究计划。这项拟议的奖项将使她能够巩固她的努力，继续她的指导活动，同时还在两个主要领域建立她的研究计划：1)中风地理和种族差异(CONTS)研究，这是一个居住在社区的30,239名黑人和白人的前瞻性队列研究；2)鼓励计划，包括两个大型的外部资助的小组随机实施的同伴支持干预试验，以改善糖尿病患者的心脏代谢参数。她的主要科学职业目标是更好地了解急性CHD结果中地区和种族差异的潜在原因，并测试旨在改善这些差异的干预措施，重点是服务不足的人群和复杂的患者，特别是糖尿病患者。自从13年前专注于心脏代谢研究以来，她作为首席调查员(PI)一直保持着总计超过1700万美元的联邦资金，并发表了159篇同行评议报告。在这段时间里，她还培养了18名临床研究员和初级临床教师的学术研究生涯，其中许多人现在在以患者为导向的研究中拥有成功的独立研究生涯。她作为UAB卫生服务研究(HSR)研究员的联合PI的职位，在任何时候都包括18名研究员，确保了潜在导师的稳定供应。她的指导目标是继续培养她的教学和指导技能，并通过她的研究计划继续为被指导者和受训者提供出色的指导，利用她在UAB HSR奖学金计划和UAB成果和有效性研究与教育中心的领导角色，在整个颁奖期间挑选有前途的候选人进行培训。她的研究目标是1)在她目前工作的基础上，研究急性冠脉综合征和听力衰竭的护理过程和结果之间的联系，将联邦医疗保险和区域资源文件数据添加到CONTS研究数据中，测试她当前工作产生的假设；4)在与候选人一起进行这些研究时，4名受试者将接受培训；2)在鼓励计划中，进行一项先导性研究，在罗杰的创新扩散理论的指导下，开发一项干预措施，通过同伴支持者传播仿制药使用的可接受性，旨在测试干预措施将改善服药依从性，进而提高心脏代谢风险因素水平的假设；4名受试者将接受培训，并与候选人一起进行这些研究。在UAB的大力支持和协作环境下，该奖项将允许Safford博士继续建立她的研究项目，并利用她对指导的坚定承诺，目前包括6名职业发展奖获得者以及4名T-32研究员。

DESCRIPTION (provided by applicant): Monika M. Safford, MD is Associate Professor of Medicine at the University of Alabama at Birmingham (UAB), where she has built a successful research program in observational and implementation research. This proposed award will permit her to consolidate her effort to continue her mentoring activities while also building her research program in two main areas: 1) in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a community-dwelling prospective cohort of 30,239 Black and White individuals; and 2) the Encourage program, which consists of two large extramurally funded group-randomized implementation trials of peer support interventions to improve cardiometabolic parameters in individuals with diabetes. Her main scientific career goals are to better understand underlying reasons for regional and racial disparities in acute CHD outcomes, and to test interventions designed to improve them, with a focus on underserved populations and complex patients, especially those with diabetes. Since focusing her career on cardiometabolic research 13 years ago, she has maintained uninterrupted federal funding totaling over $17 million as Principal Investigator (PI) and has published 159 peer-reviewed reports. Over this time, she has also fostered the academic research careers of 18 clinical fellows and junior clinical faculty, many of whom now have successful independent research careers in patient-oriented research. Her position as Co-PI of the UAB Health Services Research (HSR) Fellowship, which includes 18 Fellows at any time, assures a steady supply of potential mentees. Her Mentoring Aims are to continue to build her teaching and mentoring skills, and to continue to provide outstanding mentorship to mentees and trainees through her research program, leveraging her leadership roles in the UAB HSR Fellowship program and the UAB Center for Outcomes and Effectiveness Research and Education to select promising candidates for training throughout the award period. Her Research Aims are 1) to build on her current work to study the link between processes of care and outcomes for acute coronary syndrome and hear failure, by adding Medicare and Area Resource File data to the REGARDS study data, testing hypotheses generated by her current work; 4 mentees will receive training while conducting these studies with the candidate; 2) In the Encourage program, to conduct a pilot study that takes the next step in her intervention work, developing an intervention guided by Roger's Diffusion of Innovations theory to spread the acceptability of generic medication use via peer supporters, aiming to test the hypothesis that the intervention will improve medication adherence and, in turn, cardiometabolic risk factor levels; 4 mentees will receive training and conduct these studies with the candidate. In the strongly supportive and collaborative environment of UAB, this award will permit Dr. Safford to continue to build her research program as well as capitalizing on her deep commitment to mentoring, now including six career development award recipients, as well as four T-32 fellows.