Mood, Physiological Arousal, and Alcohol Use

描述(申请人提供)：这个项目将实时检测情绪、自主神经高唤醒和酒精使用之间的关系，并确定实验室中对标准刺激的自主神经高唤醒反应是否与日常生活中的情感-酒精关系有关。方法使用动态生理和自我报告评估，情绪调节有困难(即符合临界人格障碍标准)和社区控制的参与者将在一周的过程中提供有关情绪和饮酒的信息。自主神经高反应性也将在实验室进行评估，以便为实时数据提供比较。该项目的长期目标结果将为酒精使用的负面强化模型提供信息，并帮助确定酒精使用障碍的生理内表型。培训目标奖学金申请者将学习自主神经系统功能、心理生理学数据分析、密集纵向数据分析，并将获得在适当的科学期刊上交流这项研究成果的经验。这将为申请者的职业生涯做好准备，使用翻译研究来研究酒精使用的生理和情感风险因素。

DESCRIPTION (provided by applicant): This project will examine the relation between mood, autonomic hyper-arousal, and alcohol use in real-time, and determine whether autonomic hyper-arousal responses to standard stimuli in the laboratory are related to affect-alcohol relations in daily life. Method Using ambulatory physiological and self-report assessments, participants with difficulties in emotion regulation (i.e., meet criteria for borderline personalit disorder) and community controls will provide information regarding mood and drinking over the course of a week. Autonomic hyper-reactivity will also be assessed in the laboratory, in order to provide a comparison for real-time data. Long-Term Objectives Results from this project will inform negative reinforcement models of alcohol use and help identify physiological endophenotypes for alcohol use disorders. Training Aims The fellowship applicant will learn about autonomic nervous system functioning, analysis of psychophysiological data, analysis of intensive longitudinal data, and will gain experience communicating findings from this study in appropriate scientific journals. This will prepare the applicant for a career using translational research to study physiological and affective risk factors for alcohol use.