Effectiveness of the Influenza Vaccine in the Aging Population

描述(由研究人员提供)：本研究申请是对现有数据库的二次分析，以响应计划公告PA-09-265：对现有数据集和存储的生物样本进行二次分析，以解决临床老龄化研究问题(R01)，以确定流感疫苗在老年人中的有效性。最近的工作表明，需要更多地了解流感疫苗在老年人中的有效性以及用于确定疫苗有效性的方法。这个数据库是三项研究的累积，这些研究前瞻性地测试了老年人的流感。这些数据将被用来确定目前的试验阴性对照方法是否真的会控制 脆弱性的偏差将决定疫苗在非常老的人群中的有效性，并将探索疫苗制造过程是否会影响有效性。

DESCRIPTION (provided by investigator): This study application is a secondary analysis of an existing database in response to the Program Announcement, PA-09-265: Secondary Analyses of Existing Data Sets and Stored BioSpecimens to Address Clinical Aging Research Questions (R01) to determine influenza vaccine effectiveness in older adults. Recent work has shown that more is needed to be known about influenza vaccine effectiveness in older adults and the methodology used to determine that vaccine effectiveness. This database is an accumulation of three studies that prospectively tested older adults for influenza. This data will be used to determine if the current methodology of test-negative controls will actually control for the bias of frailty, will determine vaccine effectiveness in the very old, and will explore if vaccne manufacturing process impacts effectiveness.