Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine

描述（由申请人提供）：本提案记录了弗吉尼亚大学（UVA）对NHLBI/NINDS申办的心血管医学心胸外科研究网络（网络）的贡献，并支持该研究中心作为核心临床中心参与该网络。本提案中包括一项技能发展方案。UVA每年进行1，050例成人心血管手术，可作为临床研究的最高优先级进行招募。我们的团队为各种具有挑战性的心胸外科试验展示了患者招募和保留的创新方法。UVA调查小组由系主任欧文L博士领导。Kron，心胸和血管外科医生。他曾在NHLBI担任多个国家领导职务。NINDS资助了Karen C博士。约翰斯顿是一位全国公认的血管认证神经学家，在临床试验、神经保护和结局研究方面具有重要的专业知识，在开发和开展具有挑战性的临床试验方面发挥着关键作用。在该网络的第一个资助期间，心胸外科医生Gorav Ailawadi博士在UVA的成功筛选和招募中发挥了关键作用，并为研究假设和试验开发提供了创新想法。此外，约翰登特博士，一个全国知名的心脏病专家，提供具体的专业知识，超声心动图，因为它适用于心脏瓣膜病。UVA心导管实验室主任、介入心脏病学家Michael Ragosta博士组成了领导团队。经验丰富的注册护士临床协调员提供试验管理;既往网络试验的合规记录证明了上级的试验性能。这种独特的心脏手术，中风神经学/神经学结果和心脏病学的融合保证了UVA将继续为网络做出实质性贡献。我们的具体目标：描述UVA的经验，专业知识和协作性质，在胸心血管外科，心脏病学，神经病学和公共卫生科学之间，这将大大有助于心血管医学心胸外科研究网络的成功。

DESCRIPTION (provided by applicant): This proposal documents the contributions of the University of Virginia (UVA) to the NHLBI/NINDS sponsored Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine (Network) and supports participation of the site as a Core Clinical Center within the Network going forward. A Skills Development Program is included with this proposal. UVA performs 1,050 adult cardiovascular surgeries procedures annually which are available for recruitment as the highest priority for clinical research. Our team demonstrates innovative approaches to patient recruitment and retention for a wide variety of challenging cardiothoracic surgical trials. The UVA investigative group is led by Department Chairman Dr. Irving L. Kron, a cardiothoracic and vascular surgeon. He has served in multiple national leadership roles with NHLBI. NINDS funded Dr. Karen C. Johnston, a nationally recognized vascular certified neurologist with significant expertise in clinical trials, neuroprotection, and outcomes research, plays a key role for the site in the development and conduct of challenging clinical trials. During the first funding period of the Network, cardiothoracic surgeon Dr. Gorav Ailawadi played a key role in successful screening and recruitment for UVA, and provides innovative ideas for research hypotheses and trial development. Additionally, Dr. John Dent, a nationally known cardiologist, provides specific expertise in echocardiography as it applies to valvular heart disease. Interventional cardiologist Dr. Michael Ragosta, Director of the UVA Cardiac Catheterization Laboratory, rounds out the leadership team. Experienced Registered Nurse clinical coordinators provide trial management; and compliance records from previous Network trials document superior trial performance. This unique blend of cardiac surgery, stroke neurology/neurological outcomes, and cardiology guarantee that UVA will continue to make substantive contributions to the Network. Our specific aim: To describe the experience, expertise and collaborative nature at UVA, among Thoracic and Cardiovascular Surgery, Cardiology, Neurology, and Public Health Sciences, that will substantially contribute to the success of the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine.