Administration, Bioinformatics and Biostatistics Core

在这个项目中，“肺癌中的系统生物化学：从机理上理解” 我们的目标是更好地了解肺癌的基本生物化学。 以机制为基础的可靠早期发现疾病的先决条件，以及改进的方法 治疗。行政、生物信息学和生物统计核心的作用是全面提供 管理和监督项目主任和核心领导(TW-M)。范军，博士，项目1；严军， M.D.，Ph.D.，Project 2；A.N.Lane，Ph.D.，Project 3；R.M.，Higashi，Ph.D.，Core B，Analytical) 计划项目。此外，生物统计学和信息学支持(领导S.N.Rai、博士和H.N.B 莫斯利博士)这些项目将通过这一核心提供。为确保 方案，行政核心将负责维持预算和成本报告 项目和核心以及协调年度报告、项目人员定期会议和 内部和外部咨询委员会。生物信息学/生物统计学的主要目标 这一核心的一部分是为执行翻译研究和信息学的调查人员提供支持 用于生化途径重建和通量建模。核心服务与以下需求相匹配 每个项目并涵盖从协作到日常服务的全方位服务；协议准备 和审查；发展信息学方法以确保互操作性；以及生化网络 分析。

In this Program Project "Systems Biochemistry in Lung Cancer: toward a mechanistic understanding of NSCLC" we aim to achieve a better understanding of the basic biochemistry of lung cancers as a prerequisite to mechanism-based reliable early detection of the disease, and to improved approaches to treatment. The role of the Administrative, Bioinformatics and Biostatistics Core is to provide overall administration and oversight to the project directors and core leaders (T. W-M. Fan, Ph.D., Project 1; J. Yan, M.D., Ph.D., Project 2; A. N. Lane, Ph.D., Project 3; R. M, Higashi, Ph.D., Core B, Analytical) on this Program Project. In addition, Biostatistics and Informatics support (leaders S. N. Rai, Ph.D. and H. N. B Moseley, Ph.D.) for the Projects will be provided through this Core. To ensure smooth interoperability of the program, the administrative core will be responsible for maintaining the budgets and cost reporting of the projects and cores as well as coordinating annual reports, regular meetings among the project personnel and the internal and external advisory committees. The primary objective of the Bioinformatics / Biostatistics portion of this core is to provide support for investigators performing translational research and Informatics for biochemical pathway reconstruction and flux modeling. The core services are matched to the needs of each project and cover a full range of services from collaboration and routine service; protocol preparation and review; development of informatics approaches to ensure interoperability; and biochemical network analysis.