A Drosophila Model Investigates the Role of Metals in Initiating Urinary Stones

这项建议旨在建立一个研究尿路结石的跨学科研究中心。 加州大学旧金山分校的疾病。肾结石是一种良性的泌尿系统疾病 每年影响数以百万计的美国人。我们的研究发现，非钙金属可能会起到 在肾结石钙化的启动过程中起着关键作用。我们已经证明了钙化过程 潜在的结石形成可能在广泛的疾病中共享，包括动脉粥样硬化和 骨质疏松。因此，我们建立了一个跨学科合作伙伴网络，以探索这些问题 关系。这其中包括遗传学、金属代谢、先进成像和生理学方面的专家。 我们提议的核心研究项目集中于促进我们对金属如何 利用一种新的果蝇黑腹果蝇在钙化和肾结石形成中发挥关键作用 尿路结石病模型。工作将与奥布赖恩的合作者一起进行 梅奥诊所的泌尿学研究中心、巴克老龄化研究所和儿童医院 奥克兰研究中心医院。这个核心项目将把不同的学科和不同的 机构从新的和广泛的角度来认识尿路结石疾病。 这项提案的中心主任马歇尔·斯托勒博士带来了超过25年的跨学科经验 作为加州大学旧金山分校尿石科的负责人，向领导团队提供研究和临床经验， 完全有资格管理这个中心。我们的行政核心将支持一项教育计划，该计划将带来 与其他不同的矿化角度一起研究泌尿系结石疾病 举办讲习班，为这一领域的研究开展新的对话和合作努力。 该中心的建立将对推进中国的合作研究产生重大影响 良性泌尿外科领域以及我们对泌尿系结石疾病的认识和治疗。

This proposal seeks to develop a cross-disciplinary research center for the study of urinary stone disease at the University of California, San Francisco. Kidney stones are a benign urologic disease affecting millions of Americans annually. Our research has discovered that non-calcium metals may play a critical role in initiating kidney stone calcification. We have demonstrated that the calcification process underlying stone formation may be shared across a broad range of diseases, including atherosclerosis and osteoporosis. We have therefore established a network of cross-disciplinary collaborators to explore these connections. This include experts in genetics, metal metabolism, advanced imaging, and physiology. Our proposed core research project focuses on advancing our understanding of how metals may play a critical role in calcification and kidney stone formation utilizing a novel Drosophila melanogaster model for urinary stone disease. Work will be performed in conjunction with collaborators at the O'Brien Urology Research Center at the Mayo Clinic, the Buck Institute for Research on Aging, and the Children's Hospital of Oakland Research Center. This core project will bring together different disciplines and different institutions to approach understanding urinary stone disease from a new and broad viewpoint. Dr. Marshall Stoller, the Center Director for this proposal, brings more than 25 years of cross-disciplinary research and clinical experience to the leadership team and as the head of the UCSF urinary stone division, is well qualified to run the center. Our administrative core will support an educational program that will bring together additional diverse perspectives on mineralization for the study of urinary stone disease with a series of workshops that will develop new dialogues and collaborative efforts for research in this field. Establishment of this center will make a significant impact on advancing collaborative research in the field of benign urology and our understanding and treatment of urinary stone disease.