A Drosophila Model Investigates the Role of Metals in Initiating Urinary Stones

果蝇模型研究金属在引发尿路结石中的作用

• 批准号: 8852289
• 负责人: Marshall Stoller
• 金额: $ 3.48万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2015-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8852289
• 关键词: Affect; Aging; American; Atherosclerosis; Benign; Calculi; California; Clinic; Clinical; Discipline; Disease; Drosophila genus; Drosophila melanogaster; Educational workshop; Functional disorder; Genetic; Head; Image; Institution; Kidney Calculi; Leadership; Marshal; Metals; Modeling; Morbidity - disease rate; Osteoporosis; Outpatients; Patients; Pediatric Hospitals; Physiology; Play; Process; Published Comment; Qualifying; Research; Research Institute; Research Project Grants; Role; Running; San Francisco; Series; Universities; Urinary Calculi; Urologic Diseases; Urology; Work; calcification; cost; experience; medical specialties; metal metabolism; mineralization; novel; programs

This proposal seeks to develop a cross-disciplinary research center for the study of urinary stone disease at the University of California, San Francisco. Kidney stones are a benign urologic disease affecting millions of Americans annually. Our research has discovered that non-calcium metals may play a critical role in initiating kidney stone calcification. We have demonstrated that the calcification process underlying stone formation may be shared across a broad range of diseases, including atherosclerosis and osteoporosis. We have therefore established a network of cross-disciplinary collaborators to explore these connections. This include experts in genetics, metal metabolism, advanced imaging, and physiology. Our proposed core research project focuses on advancing our understanding of how metals may play a critical role in calcification and kidney stone formation utilizing a novel Drosophila melanogaster model for urinary stone disease. Work will be performed in conjunction with collaborators at the O'Brien Urology Research Center at the Mayo Clinic, the Buck Institute for Research on Aging, and the Children's Hospital of Oakland Research Center. This core project will bring together different disciplines and different institutions to approach understanding urinary stone disease from a new and broad viewpoint. Dr. Marshall Stoller, the Center Director for this proposal, brings more than 25 years of cross-disciplinary research and clinical experience to the leadership team and as the head of the UCSF urinary stone division, is well qualified to run the center. Our administrative core will support an educational program that will bring together additional diverse perspectives on mineralization for the study of urinary stone disease with a series of workshops that will develop new dialogues and collaborative efforts for research in this field. Establishment of this center will make a significant impact on advancing collaborative research in the field of benign urology and our understanding and treatment of urinary stone disease.

该提案旨在建立一个跨学科研究中心来研究泌尿系结石 加州大学旧金山分校的疾病。肾结石是一种良性泌尿系统疾病 每年影响数百万美国人。我们的研究发现，非钙金属可能起到 在启动肾结石钙化中起关键作用。我们已经证明钙化过程 潜在的结石形成可能是多种疾病共有的，包括动脉粥样硬化和 骨质疏松症。因此，我们建立了一个跨学科合作者网络来探索这些 连接。其中包括遗传学、金属代谢、高级成像和生理学方面的专家。 我们提出的核心研究项目侧重于增进我们对金属如何发挥作用的理解 利用新型果蝇在钙化和肾结石形成中发挥关键作用 泌尿系结石疾病模型。工作将与奥布莱恩的合作者一起进行 梅奥诊所泌尿学研究中心、巴克衰老研究所和儿童医院 奥克兰研究中心医院。这个核心项目将汇集不同学科和不同领域 机构从新的、广泛的角度来了解泌尿系结石疾病。 该提案的中心主任 Marshall Stoller 博士带来了超过 25 年的跨学科研究经验 领导团队以及作为 UCSF 泌尿系结石科负责人的研究和临床经验， 具备管理该中心的资格。我们的行政核心将支持一项教育计划，该计划将带来 结合其他关于矿化的不同观点来研究泌尿系结石疾病，并进行了一系列研究 研讨会将为该领域的研究开展新的对话和合作努力。 该中心的成立将对推进我国的合作研究产生重大影响。 良性泌尿外科领域以及我们对泌尿系结石疾病的理解和治疗。