A Drosophila Model Investigates the Role of Metals in Initiating Urinary Stones

这项建议旨在发展一个跨学科的研究中心，研究泌尿系结石 疾病在加州大学，旧金山弗朗西斯科。肾结石是一种良性泌尿系统疾病 每年影响数百万美国人我们的研究发现，非钙金属可能发挥了 在启动肾结石钙化中起关键作用。我们已经证明了钙化过程 潜在的结石形成可以在广泛的疾病中共享，包括动脉粥样硬化和 骨质疏松因此，我们建立了一个跨学科合作者网络，以探索这些 连接.这包括遗传学、金属代谢、高级成像和生理学方面的专家。 我们提出的核心研究项目的重点是推进我们对金属如何可能 在钙化和肾结石形成中发挥关键作用， 泌尿系结石病模型。工作将与奥布莱恩的合作者一起进行 马约诊所泌尿学研究中心、巴克老龄化研究所和儿童医院 奥克兰研究中心医院。这个核心项目将汇集不同的学科和不同的 从一个新的和广泛的角度来认识泌尿系结石疾病。 博士马歇尔斯托勒，该中心主任为这项建议，带来了超过25年的跨学科 研究和临床经验的领导团队，并作为UCSF泌尿系结石部门的负责人， 完全有资格管理中心我们的行政核心将支持一项教育计划， 结合矿化的其他不同观点，用于泌尿系结石疾病的研究， 这些讲习班将为这一领域的研究发展新的对话和合作努力。 该中心的成立将对推进合作研究产生重大影响， 良性泌尿外科领域以及我们对泌尿系结石疾病的认识和治疗。

This proposal seeks to develop a cross-disciplinary research center for the study of urinary stone disease at the University of California, San Francisco. Kidney stones are a benign urologic disease affecting millions of Americans annually. Our research has discovered that non-calcium metals may play a critical role in initiating kidney stone calcification. We have demonstrated that the calcification process underlying stone formation may be shared across a broad range of diseases, including atherosclerosis and osteoporosis. We have therefore established a network of cross-disciplinary collaborators to explore these connections. This include experts in genetics, metal metabolism, advanced imaging, and physiology. Our proposed core research project focuses on advancing our understanding of how metals may play a critical role in calcification and kidney stone formation utilizing a novel Drosophila melanogaster model for urinary stone disease. Work will be performed in conjunction with collaborators at the O'Brien Urology Research Center at the Mayo Clinic, the Buck Institute for Research on Aging, and the Children's Hospital of Oakland Research Center. This core project will bring together different disciplines and different institutions to approach understanding urinary stone disease from a new and broad viewpoint. Dr. Marshall Stoller, the Center Director for this proposal, brings more than 25 years of cross-disciplinary research and clinical experience to the leadership team and as the head of the UCSF urinary stone division, is well qualified to run the center. Our administrative core will support an educational program that will bring together additional diverse perspectives on mineralization for the study of urinary stone disease with a series of workshops that will develop new dialogues and collaborative efforts for research in this field. Establishment of this center will make a significant impact on advancing collaborative research in the field of benign urology and our understanding and treatment of urinary stone disease.