Interactions between host and the gut microbiome in the pathogenesis of ankylosing spondylitis and Crohn's disease

强直性脊柱炎(AS)和克罗恩病(CD)是常见的免疫介导性疾病，分别影响脊柱和肠道的关节。基因在决定每种疾病的风险方面发挥着重要作用，这些基因很可能是通过与某些环境因素相互作用而导致疾病的，最有可能的是驻留在肠道中的细菌。这项研究的目的是通过分析疾病患者和健康受试者肠道中的细菌来验证这一假设。

Ankylosing spondylitis (AS) and Crohn's disease (CD) are common immune-mediated diseases affecting primarily the joints of the spine and the gut respectively. Genes play a major role in determining the risk of each disease, and it is likely that those genes cause the disease by interaction with some environmental factor, most likely bacteria residing in the gut. This study aims to test that hypothesis by profiling the bacteria in the gut of patients with the diseases and healthy subjects.