Interactions between the malaria parasite's chloroquine resistance transporter and antimalarial drugs

疟疾寄生虫是一种单细胞生物，它侵入宿主的红细胞。该项目的目的是表征负责赋予氯喹抗性的寄生虫蛋白，并研究其与其他抗疟疾药物的相互作用。这种蛋白质的微小变化改变了寄生虫对氯喹和其他药物的敏感性。这项工作将促进我们对日益普遍的抗疟药物耐药性现象的理解。

The malaria parasite is a single-celled organism which invades the red blood cells of its host. The aim of this project is to characterize the parasite protein responsible for conferring resistance to chloroquine, and to study its interaction with other antimalarial drugs. The parasite's susceptibility to chloroquine, and other drugs, is altered by small changes in this protein. This work will advance our understanding of the increasingly widespread phenomenon of antimalarial drug resistance.