Analytic Genomics and Transgenics Core

分析基因组学和转基因核心中心(AGTC)的总体目标是提高UAB风湿病核心中心(RDCC)研究人员的工作效率，并提供最先进的服务，以促进适当的遗传动物模型的开发和使用。在前两个资助周期中，该核心基金(以前称为“基因靶向核心基金”(GTCF))作为UAB转基因小鼠基金的一部分，支持胚胎干细胞(ES)服务方面的专业知识。 根据用户需求，CORE扩展了服务范围，以更具体地协助创建与风湿病相关的小鼠模型，而不仅仅是ES服务，以1)生成对多个RDCC研究人员具有广泛实用性的新型基因工程模型，以及2)建立教育和推广计划，以在CORE和RDCC研究人员之间建立积极的合作，特别是在基因组学相关领域。 通过在UAB和我们的合作机构Hudson Alpha生物技术研究所(HAIB)举办的研讨会、研讨会、讲座和研讨会，学习现代和新兴基因和基因组技术的正式教育资源是核心进化的延伸。核心的总体目标和下游产出保持不变：制造人类疾病的小鼠模型和人类致病基因变异的模型，以便提供一个哺乳动物系统来研究风湿病的病理生理学，以及测试潜在治疗干预的有效性。 为此，分析基因组学和转基因核心有以下具体目标： 目的1.服务：提供专家服务，以生成和分析遗传/基因组数据，并开发与RDCC任务有关的翻译动物模型。 目标2.外展和教育：为RDCC调查人员提供丰富的方案。 目标3.发展：评估RDCC调查员的需求，并开发新的平台和技术来满足这些需求。

The overall goal of the Analytical Genomics and Transgenics Core (AGTC) is to enhance the productivity of the UAB Rheumatic Disease Core Center (RDCC) researchers, and provide state-of-the-art services to facilitate the development and use of appropriate genetic animal models. During the two previous funding cycles, this Core (formerly called the "Gene Targeting Core Facility" (GTCF)) served to support expertise in embryonic stem (ES) cell services as part of the UAB Transgenic Mouse Facility. In response to user needs, the Core has expanded services to more specifically assist with the creation of mouse models relevant to rheumatic disease beyond just ES services to 1) generate novel genetically engineered models of broad utility to multiple RDCC investigators, and 2) establish educational and outreach programs to forge active collaborations between the Core and RDCC investigators, especially in areas related to genomics. Formal educational resources for learning modern and emerging genetic and genomic technologies via workshops, seminars, lectures, and symposia hosted at UAB and our partner institution, Hudson Alpha Institute for Biotechnology (HAIB) are an extension of the core's evolution. The overarching objective and downstream output of the Core remains the same; to produce mouse models of human disease and of human genetic variants contributing to disease in order to provide a mammalian system to study the pathophysiology of rheumatic disease, as well as to test the efficacy of potential treatment interventions. To this end, the Analytical Genomics & Transgenic Core has the following specific aims: AIM 1. SERVICE: To provide expert services to generate and analyze genetic/genomic data, and to develop translational animal models relating to the mission of the RDCC. AIM 2. OUTREACH AND EDUCATION: To provide enrichment programs for RDCC investigators. AIM 3. DEVELOPMENT: To assess RDCC investigator needs and develop new platfonns and technologies to address those needs.