THE ROLE OF REGULATORY T CELLS IN IMMUNE CONTROL OF FLAVIVIRUS INFECTION

黄病毒在美国和全世界都是一个主要的公共卫生问题。调节性T细胞的作用 (Tregs)，适应性和先天免疫反应的强有力的负调节因子，在病毒感染中 一般情况下，尤其是在黄病毒感染方面，人们知之甚少。我们假设有不同的 影响病毒特异性Treg功能不同表现的定性和定量要求 反应和相关的病理学。这些表现可能会因病程的不同而不同。 病毒感染、定位(次级淋巴器官与周围组织)和特定病毒类型。 在本应用中，我们将使用西尼罗河病毒(WNV)感染的成熟实验模型 在小鼠身上研究Treg细胞在黄病毒感染中的作用。在我们的研究中，我们将测试 利用FoxpS8‘的优势提出上述假设

Flaviviruses present a major public health problem in the US and worldwide. A role of regulatory T cells (Tregs), potent negative regulators of the adaptive and innate immune responses, in viral infection in general, and in flayivirus infection in particular, is poorly understood. We hypothesize that there are distinct qualitative and quantitative requirements for diverse manifestations of Treg function affecting virus specific responses and associated pathology. These manifestations might vary depending on time during the course of viral infection, localization (secondary lymphoid organs vs. peripheral tissues), and the specific virus type. In this application, we will employ a well-established experimental model of West Nile virus (WNV) infection in mice to investigate a role for Treg cells in flavivirus infection. In our studies, we will test the aforementioned hypotheses by taking advantage of FoxpS8'