Novel APCI source
Novel APCI source
批准号:
8715083
负责人:
EUGENE MOSKOVETS
金额:
$16.49万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-08-01 至 2016-01-31
关键词:
AirAntibioticsAreaAtmospheric PressureBiologicalBlood capillariesChargeChemicalsComplexDetectionDisadvantagedDiseaseDrug-sensitiveElectrodesElectronsExhibitsFigs - dietaryFilamentFrequenciesGasesGoalsHeatingIntakeIonsLifeLipidsMass Spectrum AnalysisMethodsMetricMolecularMonitorNatureNebulizerOpticsPerformancePharmaceutical PreparationsPhasePhysiologic pulsePlasmaPulse RatesReagentRelative (related person)SamplingSensitivity and SpecificitySeriesSmall Business Innovation Research GrantSolventsSourceSpecificitySpeedSteroidsStreamSurfaceSystemTechniquesTestingTimeUnited States National Institutes of HealthWaterWorkanalytical toolatmospheric conditionsbasecapillarycold temperaturedesignelectric fieldimprovedinstrumention sourceionizationionization techniquemass spectrometernanosecondnovelplanetary Atmospherepreventpublic health relevancetandem mass spectrometryvaporvoltage
中文摘要
描述(申请人提供):大气压化学电离(APCI)在串联质谱(MS/MS)中的效率和速度的显著提高将对其在药物、代谢物、脂质、类固醇、基于APCI的MS分析的广泛适用性使其成为专门针对痕量的许多化学和生物物质的独特分析工具。我们计划建立一种基于大气压介质阻挡放电(DBD)的新型APCI离子源,以显著提高基于ACPI-MS的检测方法的效率和特异性。
英文摘要
DESCRIPTION (provided by applicant): Significant increase in the efficiency and speed of atmospheric pressure chemical ionization (APCI) in tandem mass spectrometry (MS/MS) will have a profound impact on its applications to the entire analytical field of characterization of drugs, metabolites, lipids, steroids, etc. A broad applicability of APCI-based MS analysis makes it a unique analytical tool specifically targeting trace amounts of many chemical and biological substances. We plan to build a novel APCI ion source based on atmospheric dielectric barrier discharge (DBD) to significantly improve efficiency and specificity of ACPI-MS based detection method.
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