South Carolina Research Center for Recovery from Stroke

描述（由申请人提供）：南卡罗来纳州中风康复研究中心（SCRCRS）的总体目标是在中风康复方面开展杰出的多学科合作研究。中风对南卡罗来纳州来说具有独特的重要性，因为不成比例的发病率导致中风后残疾带来不应有的经济/社会负担。我们的组织理念是，更好地理解神经可塑性的经验依赖性质，将使我们能够调查和利用固有的神经恢复过程，开发和翻译新的基于机制的干预策略，并最终改善中风患者的功能和生活质量。具体目标是：1)培养和指导一批精通多个领域的初级科学家骨干；2)开发创新的科学核心资源，旨在推进动物和人类脑卒中康复研究；3)通过发展多学科转化研究项目和严格的评估和改进策略，促进SCRCRS的长期可行性。

DESCRIPTION (provided by applicant): The overall goal of the South Carolina Research Center for Recovery from Stroke (SCRCRS) is to enable outstanding multidisciplinary collaborative research in recovery from stroke. Stroke is of unique importance to South Carolina as a disproportionate rate of incidence results in undue economic/social burdens from post-stroke disability. Our organizing concept is that better understanding of the experience-dependent nature of neural plasticity will allow us to investigate and exploit inherent neural recovery processes, develop and translate novel mechanism- based interventional strategies, and ultimately improve the function and quality of life of individuals recovering from stroke. The specific aims are to: 1) train and mentor a cadre of junior scientists who are skilled in multiple domains; 2) develop innovative scientific core resources designed to advance stroke recovery research in animal and human studies; and 3) promote the long-term viability of the SCRCRS through development of multidisciplinary translational research programs and rigorous evaluation and improvement strategies. The Center is led by a multidisciplinary team, comprised of a PhD biomedical engineer/biomechanical scientist and an MD/clinical stroke expert, coalescing resources and disciplines from schools of medicine and allied health sciences. Scientific cores include the Quantitative Behavioral Assessment and Rehabilitation Core to provide standardized experience and quantitative measurement of behavior and function; Brain Stimulation Core to provide a plasticity modifying adjuvant for treatment and quantitative measurement of plasticity and neurophysiology; Neuroimaging Core to provide quantitative measurement of plasticity and structural and functional connectivity; and Clinical & Translational Tools and Resources Core to facilitate the development of a queriable, secure Stroke Clinical Registry Database via a robust interface with MUSC's CTSA. All Junior Investigators (Jls) will investigate some aspect of stroke recovery, with initial focus on upper extremity function, locomotion and alleviation of depression, using a suite of measurement tools rarely found in stroke recovery research settings. Innovative features of the Center include the interprofessional and multidisciplinary expertise of core leaders and Jls; the integration of motion capture and clinical assessment tools, brain stimulation tools, neuroimaging tools, and resources for biostatistics and patient record management applied to stroke recovery research; and a novel 'multiple source mentoring' approach to prepare the Jls as future leaders in clinical and translational research in recovery from stroke. Extensive institutional support - including flexible funds, new faculty recruitment an capital Improvements - will underwrite the Center's long-term success and viability.