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中文摘要
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描述(由申请人提供):NYULMC是纽约市一个领先的医疗保健、生物医学研究、教育和公共服务中心。飓风桑迪对NYULMC的研究基础设施造成了灾难性的破坏。结果,两个动物设施,Smilow地窖动物园和MSB动物园无法用于研究。该提案的目的是恢复啮齿动物屏障和无屏障住房。此外,在飓风发生时,国家卫生研究所(NIH)资助的G20翻新赠款(RR-030901)正在MSB饲养场进行。由于MSB不再可用于研究,因此本提案的目的也旨在恢复G20的目的之一。拟议的施工将在NYULMC主校区的NSB进行。这一研究基础设施的更换将能够支持调查人员,目前每年的活动研究补助金总额为81 116 830美元,待付研究赠款金为116 218 917美元。本提案中包括的恢复将影响NYULMC动物研究的能力和质量,这是留住现有研究人员所必需的,并使NYULMC几乎所有基础科学部门的教师能够额外招聘。
英文摘要
DESCRIPTION (provided by applicant): NYULMC is a leading center of excellence in health care, biomedical research, education, and public service in New York City. Hurricane Sandy resulted in catastrophic damage to NYULMC research infrastructure. As a result, two animal facilities, the Smilow cellar vivarium and the MSB vivarium were rendered unusable for research. The Aims of this proposal are to restore rodent barrier and non-barrier housing. In addition, at the time of the hurricane, a National Institute of health (NIH)-funded G20 renovation grant (RR-030901) was underway in the MSB vivarium. As MSB is no longer usable for research, the Aims of this proposal seek to recover one of the G20 Aims as well. The proposed construction will take place above grade at the NSB on the NYULMC main campus. This replacement of research infrastructure will be able to support investigators with a current annual total of $81,116,830 in active and $116,218,917 in pending research grants. The restoration included in this proposal will impact the capacity and quality of animal research at NYULMC necessary to retain existing investigators and enable additional recruitment of faculty in almost all of the basic science departments at NYULMC.
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A novel monobody-drug conjugate to treat mutant KRas pancreatic cancer.
  • 批准号:
    10666997
  • 项目类别:
  • 资助金额:
    $21.0万
  • 财政年份:
    2022
  • 负责人:
    DAFNA BAR-SAGI
  • 依托单位:
A novel monobody-drug conjugate to treat mutant KRas pancreatic cancer.
  • 批准号:
    10323748
  • 项目类别:
  • 资助金额:
    $39.87万
  • 财政年份:
    2021
  • 负责人:
    DAFNA BAR-SAGI
  • 依托单位:
A novel monobody-drug conjugate to treat mutant Ras multiple myeloma
  • 批准号:
    10080987
  • 项目类别:
  • 资助金额:
    $39.99万
  • 财政年份:
    2020
  • 负责人:
    DAFNA BAR-SAGI
  • 依托单位:
Dectin-1 signaling drives pancreatic oncogenesis by inducing macrophage-mediated adaptive immune suppression
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