Combined effects of HIV, age and race on inflammation-related brain abnormalitie

项目总结(见说明)： 尽管高效抗逆转录病毒疗法(HAART)成功地降低了艾滋病毒和 显著延长预期寿命，艾滋病毒感染(HIV阳性)患者患慢性病的风险更高 进行性疾病，包括艾滋病毒相关性痴呆症。因为HIV阳性的患者往往 据推测，这些情况比未感染艾滋病毒(艾滋病毒阴性)的人更早发生 艾滋病毒的存在加速了器官的终末衰老。然而，人们对此知之甚少。 艾滋病毒引起的脑部早衰。核磁共振成像(MRI)显示了大脑的结构性 没有明显疾病的老年人和艾滋病毒阳性者的异常，甚至在弗兰克之前 认知和运动障碍就会出现。然而，病毒和年龄的综合影响对 大脑的宏观和微观结构特征还没有得到研究。慢性炎症是 被认为是与年龄和艾滋病毒相关的结构性大脑变化的主要贡献者。然而，它的作用是 HIV和AGE对大脑残骸宏观和微观结构的联合影响中的炎症 未得到充分研究。此外，尽管非洲裔美国人在感染艾滋病的人中所占比例最大 艾滋病毒，并处于与炎症相关的慢性疾病的更高风险，很少有研究 直接比较了HIV相关脑部异常的种族差异。因此，这个项目的总体目标是 是研究HIV、年龄和种族对大脑结构的综合影响，以确定 炎症在这些影响中的作用，并研究与艾滋病毒炎症相关的脑异常的相关性 认知和运动障碍。

PROJECT SUMMARY (See instructions): Although highly-active anti-retroviral therapy (HAART) successfully reduces viral load in HIV and dramatically increases life expectancy, HIV-infected (HIV-positive) patients are at higher risk for chronic progressive medical conditions including HIV-associated dementia. Since HIV-positive patients tend to develop these conditions sooner than HIV-uninfected (HIV-negative) individuals, it has been hypothesized that the presence of the HIV virus accelerates end-organ senescence. Little is known, however, about premature brain senescence in HIV. Magnetic resonance imaging (MRI) has demonstrated structural brain abnormalities in older individuals without overt disease and in HIV-positive persons, even before frank cognitive and motor impairments emerge. However, the combined effects of the virus and age on the macro- and micro-structural characteristics of the brain have not been investigated. Chronic inflammation is thought to be a major contributor to age- and HIV-related structural brain changes. However, the role of inflammation in the combined effects of HIV and age on the macro- and micro-structure of the brain remains understudied. Further, although African Americans represent the largest proportion of those infected with HIV, and are at higher risk for chronic medical conditions associated with inflammation, few studies have directly compared racial differences in HIV-related brain abnormalities. Thus, the overall goal of this project is to investigate the combined effects of HIV, age and race on brain structure, to determine the role of inflammation in these effects, and to study the association of inflammation-related brain abnormalities in HIV to cognitive and motor impairments.