Third International Conference on Cardiomyopathy in Children

描述（申请人提供）：心肌病是一种严重的心脏肌肉疾病。近40%患有心肌病的儿童接受心脏移植或在诊断后的头两年内死亡。患有心肌病的儿童接受心脏移植的比例在过去10年中没有下降，心肌病仍然是一岁以上儿童移植的主要原因。由国家心肺血液研究所（NHLBI）资助的儿科心肌病登记（PCMR）的研究表明，心肌病的病因在极少数儿童中是确定的，而遗传原因可能存在于大多数儿童中。儿童心肌病的发病率约为每10万名儿童中有1名。这与儿童癌症如淋巴瘤、肾母细胞瘤和神经母细胞瘤的发病率相当。然而，发表的关于小儿心肌病的研究和科学会议要比其他疾病少得多。第三届国际儿童心肌病会议的目的是在2007年第一次会议“特发性和原发性儿童心肌病-研究方向和策略”（由NHLBI和儿童心肌病基金会共同主办）的成功基础上，以及2010年举行的第二届国际儿童心肌病会议（由儿童心肌病基金会和心肌炎基金会共同主办，由nhlbi赞助的儿科心肌病登记处提供额外资金），以审查目前心肌病研究的知识库，包括第一届和第二届会议未涵盖的研究领域。本次会议旨在汇集包括分子生物学家、流行病学家和临床医生在内的多学科科学家（初级、中期和高级），以传播关于儿童心肌病的预防、病因、诊断、机制和治疗的最新研究，并确定该疾病未来研究的方向。预计这种跨学科的知识交流将确定数据差距和需求、未来的研究方向以及新的方法和技术，从而更好地了解这种疾病并改进干预和预防战略。

DESCRIPTION (provided by applicant): Cardiomyopathy is a serious disease of the heart muscle. Nearly 40 percent of children with cardiomyopathy receive a heart transplant or die within the first 2 years after diagnosis. The percentage of children with cardiomyopathy who received a heart transplant has not declined over the past 10 years and cardiomyopathy remains the leading cause of transplantation for children over one year of age. Studies from the National Heart, Lung, and Blood Institute (NHLBI)-funded Pediatric Cardiomyopathy Registry (PCMR) have shown that the cause of cardiomyopathy is established in very few children yet genetic causes are likely to be present in most. The incidence of pediatric cardiomyopathy is approximately 1 per 100,000 children. This is comparable to the incidence of such childhood cancers such as lymphoma, Wilms' tumor, and neuroblastoma. However, the published research and scientific conferences focused on pediatric cardiomyopathy is much less than for these other conditions. The purpose of the proposed conference, the Third International Conference on Cardiomyopathy in Children is to build on the success of the first conference, "Idiopathic and Primary Cardiomyopathy in Children- Research Directions and Strategies" held in 2007 (cosponsored by NHLBI and the Children's Cardiomyopathy Foundation), and the Second International Conference on Cardiomyopathy in Children held in 2010 (cosponsored by the Children's Cardiomyopathy Foundation and the Myocarditis Foundation with additional funding from the NHLBI-sponsored Pediatric Cardiomyopathy Registry) to review the current knowledge base from research on cardiomyopathy including research areas not covered in the first and second conferences. This meeting is designed to bring together a multidisciplinary group of scientists (entry-level, mid-career, and senior), including molecular biologists, epidemiologists and clinicians in order to disseminate the most up to date research on the prevention, etiology, diagnosis, mechanisms, and treatment of pediatric cardiomyopathy and to shape the direction of future research on the disease. It is anticipated that this interdisciplinar exchange of knowledge will identify data gaps and needs, future research directions and new approaches and technologies that will lead to a better understanding of this disease and improved intervention and prevention strategies.