Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine plus dihydroartemisinin-piperaquine to reduce adverse pregnancy outcomes and prevent malaria in Papua New Guinea: a randomised controlled trial

全世界数以百万计的孕妇因疟疾而复杂化。目前的治疗策略是每月进行磺胺嘧啶-乙胺嘧啶（SP）治疗，它不再能够预防疟疾，但通过非疟疾效果改善了分娩结果。双氢青蒿素-哌喹可清除疟疾，但与接受SP治疗的妇女相比，婴儿的体型较小。对这两种药物组合进行的临床试验有可能大大改善巴布亚新几内亚及其他地区妇女和婴儿的健康状况。

Millions of pregnancies are complicated by malaria worldwide. Monthly sulphadoxine-pyrimethamine (SP) treatments, the current treatment strategy, no longer protects from malaria but improves birth outcomes through non-malarial effects. Dihydroartemisinin-piperaquine clears malaria but babies are smaller compared to women who received SP. A clinical trial of their combination has potential to substantially improve health outcomes for women and babies in Papua New Guinea and beyond.