Interaction of pathogenic bacteria with human phagocytic leukocytes

在2014财年，我们研究了人类多形核白细胞（PMNs或中性粒细胞）在宿主防御细菌病原体中的作用。中性粒细胞对先天免疫反应抵抗入侵微生物至关重要。获得性免疫反应需要时间来形成，并依赖于先前与特定病原体的相互作用，与此相反，pmn杀死感染性微生物的能力是即时的、非特异性的，不依赖于先前的病原体暴露。由于pmn产生有毒的杀微生物成分，并且在大多数细菌感染中是主要的免疫细胞，因此控制感染诱导的炎症对于限制宿主组织破坏至关重要。我们研究的一个关键方面是研究PMNs如何摄取和杀死细菌，并阐明吞噬后的后遗症，如细胞凋亡，这是炎症消退阶段的关键过程。这些研究继续为解决人类感染提供基本见解。

In FY2014, we investigated the role played by human polymorphonuclear leukocytes (PMNs or neutrophils) in host defense against bacterial pathogens. Neutrophils are essential to the innate immune response against invading microorganisms. In contrast to the acquired immune response, which requires time to develop and is dependent on previous interaction with specific pathogens, the ability of PMNs to kill infectious microorganisms is immediate, non-specific, and not dependent on previous pathogen exposure. Inasmuch as PMNs produce toxic microbicidal components and are the predominant immune cell in most bacterial infections, moderation of infection-induced inflammation is critical for limiting host tissue destruction. A key aspect of our research investigates how PMNs ingest and kill bacteria, and elucidates post-phagocytosis sequelae such as apoptosis, processes crucial for the resolution phase of inflammation. These studies continue to provide fundamental insight into the resolution of infection in humans.