Patient Oriented Research in Kidney Disease

描述（由申请人提供）：徐志远，医学博士，理学硕士正在申请职业生涯中期研究者奖以患者为导向的研究（K24），以加强他的原始研究和指导工作。这项资助支持的新研究利用了徐博士正在进行的资助项目，并代表了他先前工作的主题扩展。它还旨在为学员提供培训机会。基本主题是在几个方面促进对肾功能急性恶化的意义和性质的理解。具体目标是：目标1：确定急性肾衰竭（ARF）/急性肾损伤（阿基）的总体人群发病率和临床重要亚组，并确定其背后的潜在驱动因素。目标二：确定肾功能突然丧失作为直接从慢性肾病（CKD）到终末期肾病（ESRD）的途径的重要性。目标3：确定急性心力衰竭时急性肾功能恶化与肾小管损伤标志物水平升高的相关程度。徐博士有一个强大的导师先前的跟踪记录，并在UCSF丰富，支持和合议的机构环境中工作。K24基金的资助将使许博士能够将更少的时间花在行政和临床责任上，而将更多的时间花在研究和指导上。

DESCRIPTION (provided by applicant): Chi-yuan Hsu, MD, MSc is applying for a Mid-career Investigator Award in Patient Oriented Research (K24) in order to augment his original research and mentorship efforts. The new research to be supported by this grant leverages Dr. Hsu's ongoing funded projects and represents thematic expansions of his prior work. It is also designed to provide training opportunities for mentees. The underlying theme is to advance understanding of the significance and nature of acute deteriorations in kidney function on several fronts. The specific aims are: Aim 1: To determine the population incidence of acute renal failure (ARF)/acute kidney injury (AKI) overall and in clinically important subgroups and to determine potential driving forces behind this. Aim 2: To determine the importance of abrupt loss of renal function as a pathway leading directly from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Aim 3: To determine the extent to which acute kidney function deterioration in the setting of acute heart failure is associated with elevated levels of markers of renal tubular injury. Dr. Hsu has a strong prior track record of mentorship and works within the rich, supportive and collegial institutional environment at UCSF. Funding from this K24 award will permit Dr. Hsu to spend less time on administrative and clinical responsibilities and more time on research and mentoring.